Clinical Study Of Blood Stasis Caused By The Stagnation Of Chill Primary Dysmenorrhea Treated With Jiajian Shaofu Zhuyu Decoction

OBJECTIVE: TO OBSERVE THE CURATIVE EFFECT AND TO EXPLORE THE THERAPENLIC MECHANISM IN TREATING BLOOD STASIS CAUSED BY THE STAGNATION OF CHILL PRIMARY DYSMENORRHEA (PD) WITH JIAJIAN SHAOFU ZHUYU (JSZ)DECOCTION. METHODS: 80 CASES OF BLOOD STASIS CAUSED BY THE STAGNATION OF CHILL PD WERE DIVIDED INTO TWO GROUPS AT RANDOM:THE TREATED GROUP WITH 40 CASES WAS EMPLOYED JSZ DECOCTION.THE CONTROL GROUP WITH 40 CASES WAS TREATED BY JSZ CAPSULE.IN THE STUDY, BEFORE AND AFTER TREATMENT,THE CLINICAL SYMPTOMS , PHYSICAL SIGNS AND THE RELATED INDEXES,SUCH AS HEMODYNAMICS,PELVIC BLOOD FLOW RESISTANCE ,SERUM ESTRADIOL(E2) AND PROGESTERONE(P) WERE OBSERVED. RESULTS:THE TOTAL EFFECTIVE PERCENTAGE OF THE TREATED GROUP WHICH WAS 97.5% WAS GREATER THAN THAT OF THE CONTROL WHICH WAS 77.5%.THE DIFFERENCE OF THE TWO GROUP WAS SIGNIFICANT (P<0.05).THE TREATMENT GROUP WAS BATTER THAN THE CONTROL GROUP IN EFFICACY SYDROMES OF TCM (P<0.05).IN THE EFFICACY OF PAIN, THE DIFFERENCE OF THE TWO GROUP WAS SIGNIFICANT (P<0.01).IN THE TIME OF THE PAIN ONSET, THE TREATMENT GROUP WAS BATTER THAN THE CONTROL GROUP (P<0.05).THE GUIDE LINE OF BLOOD RHEOLOGY WAS EVIDENTLY IMPROVED AND WAS OBVIOUSLY BETTER THAN THAT OF CONTROL GROUP (P<0.05).THE EXPONENT OF PELVIC BLOOD FLOW RESISTANCE WAS EVIDENTLY REDUCED AND WAS SIGNIFICANTLY BETTER THAN THAT IN CONTROL GROUP (P<0.05).THE E₂ LEVEL OF TREATMENT GROUP WAS OBVIOUSLY DECREASED (P<0.01).BUT THE P LEVEL OF TREATMENT GROUP OBVIOUSLY INCREASED (P<0.01). CONCLUSION: JIAJIAN SHAOFU ZHUYU DECOCTION IS AN EFFECTIVE RECIPE IN TREATING PD,THE EFFECT CAN BE ACHIEVED BY IMPROVING THE SYMPTOM AND SIGN; JSZ DECOCTION MAY REDUCE BLOOD ROPY EXTENT,ACCELERATE BLOOD CIRCLE;IMPROVE BASIN ANTRUM BLOOD CIRCLE,REDUCE BLOOD RESISTANCE;REGULATE OVARIAN HORMONE LEVEL,ADJUST THE MIND AND EMOTION,PROMOTE THE HOMEOSTATIC EQUILIBRIUM OF ORGANISM AND CONSOLIDATE CURATIVE EFFECT.