Heparin,PGE1 On Ultrasound-Mediated Transdermal Drug Transport System And Their Effects On Flap Survival In The Pigs

Objective To investigate the possibility and the methods for UMTDT of heparin andPGE1, and the effects of them by UMTDT on the flap survival. MethodsFirst,determine the ultrasound safe power and intensity to pig skin in vivo.Then therandom skin flap survival rates were measured using photo-analysis system followingUMTDT of heparin and PGE1 respectively,All results were analyzed with SAS 8.12.Results The low-frequency ultrasound had not obvious harm to the pig skin macroscopically and after the low-frequency ultrasound (20K) treatment with aintensity 10W/cm2 for 2 min and 3W/cm2 for 5 min was performed. Flap survival ratein the groups of applicating heparin and PGE1 both enhanced significantly, themethod of using heparin and PGE1 combinately enhanced flap survival rate totally to92.5%,when compared with the control group (p<0.01).Conclusion UMTDT ofheparin and PGE1 was simple and safe, and it can enhance survival rates of randompattern skin flap. Thus it may provides a potential alternative to injections.