The Correlation Between ANA, C3, C4, Anti-dsDNA Antibody And Anti-ENA Antibody With The Lupus Nephritis And Global Disease Activity

Objective: To establish the correlation between autoantibodies and other lab values with the lupus nephritis and global disease activity using cross-sectional data in patients with systemic lupus erythematosus (SLE).Patients and methods: A cross-sectional case-control study was designed of 66 patients with LN, and randomly selected 75 patients with SLE without nephritis as control. And all the 141 patients were assessed by using the BILAG index.With the score of the index, patients are divided to two new groups, active group and inactive group.Standard methods were used for laboratory testing.Results: Compared with inactive group of SLE, active group show significantly higher proportions of anti-Sm antibody, anti-dsDNA antibody, anti-nRNP antibody, anti-RIB antibody, and lower level of C3(p=0.039, p=0.025,p=0.020, p=0.010, p=0.010,respectively). A higher proportion of anti-dsDNA antibody and low level C3 was seen in the group with nephritis (p=0.017, p=0.010, respectively) compareing with the the group without nephritis. Conclusion: Correlation was demonstrated between C3, anti-dsDNA antibody with lupus nephritis.And there is a strong correlation between the level of C3, anti-Sm antibody, anti-dsDNA antibody, anti-nRNP antibody, anti-RIB antibody with disease activity in patients as measured by BILAG.