The Circulatory RAS Activity In Hyperlipidemic Patients And The Effects Of Statins Treatment

Objective To investigate the change of circulatory RAS activity in hyperlipidemic patients and the effects of statins.Methods 27 adults with normal lipid were selected as control, 30 people with primary mixed type hyperlipidemia (mainly hypercholesterolemia) patients were selected as treatment group. Fasting blood sample was obtained at pre-treatment (0W), 4 weeks (4W) and 8 weeks (8W) after treating with statins, to detect total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), Angiotensin-Converting Enzyme (ACE) activity and Angiotensin II (AngII) level in plasma, meanwhile, heart rate(HR), blood pressure(BP) and blood glucose(GLU) were detected. ACE activity was measured by ultraviolet spectrophotometry, the level of AngII was determined by radioimmunoassay.Result (1) Compared with control, TC,TG and LDL-C in treatment group increased significantly, the same as ACE activity and the concentration of AngII. The baseline levels of two groups(with or without statins treatment) showed that ACE activity was significantly positive correlation with TC(r=0.664), TG(r=0.369)and LDL-C(r=0.424), and AngII level was significantly positive correlation with TC(r=0.489)and LDL-C(r=0.477). (2) Compared with pre-treatment, TC, LDL-C and TG decreased significantly at 4W and at 8 W after intervention with statins, but the amplitude became lower at the second 4W. ACE activity and AngII level reduced significantly at 4W and 8W. NO significant relationship was detected between ACE activity or AngII level and any lipid parameter during our study, which showed that the change of blood lipid parameters was not proportional to ACE activity and AngII level.Conclusion The circulatory RAS activity increases in hyperlipidemic patients, TC, LDL-C and RAS activity can be reduced significantly by statins. The decreasing amplitude of TC and LDL-C is not proportional to the decreasing amplitude of the ACE activity and AngII level, indicating that statins decreased RAS activity incompletely depending on its effect on blood lipid regulation.