| As a novel approach of drug delivery,transdermal drug delivery will be one of the most important way to delivery drug.The traditional transdermal drug delivery is a passive way, which is severely limited by the barrier of the skin.By disrupting the stratum corneum structure and create pathways allowing transport of macromolecules, microneedles array can improve the transdermal drug delivery and increase the efficiency.For the purpose of promoting the level of the advanced drug delivery technique,the thesis studies and designs certain kinds of microneedles array,which possesses good mechanics property and performance of increasing the transdermal drug delivery.After reviewing the development of the microneedles array, the thesis proposes the requirement for the microneedles array for transdermal drug delivery and put forward a feasible way to design and fabricate the array.Considering the situation of the country,the thesis describes a way to fabricate the stainless steel microneedles array,which is based on the traditional metal etch process.Several kinds of microneedles array are fabricated and the outcomes are observed by a digital camera and a microscope in order to analyse the factors that affect the effects of the fabrication.Considering the use of the stainless steel microneedles array, a platform is constructed,and the mechanics characteristic of microneedles array is tested by insertion into an apple and the pig skin.The force that penetrates the corneum is 64N.The capability of enhancing transdermal drug delivery of stainless steel microneedles arrays is studied too. Certain kinds of microneedles array are inserted into the skin of Wister rats in vitro to deliver podophyllotoxin, and the penetrating effect with arrays of different needle shape are compared,as well as the influence of insertion time.And the results show that the microneedles array with a sharpened microneedle tip has the best capability to enhance the transdermal drug delivery. |
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