Maternal Plasma Resistin Levels And Their Relationship To Insulin And Glucose In Pregnant Women With Gestational Diabetes Mellitus

[Objective] To investigate the changes in resistin levels and the relationship between the substonle and insulin glucose in pregnant women with gestational diabetes mellitus (GDM).[Methods] ELISA was used to measure the resistin levels at fating in 25 patients with GDM and 30 normal pregnant women, In each pregnant women, fasting glucose levels were measured by glucose oxidase method. Fasting plasma insulin levels by electrochemilum inescent immunoassays.[Results] The Plasma resistin Levels in pregnant women with GDM and normal pregnant women were (15.32±4.26)μg/L and (11.08±1.52)μg/L, respectively, Suggesting the plasma resistin levels were significantly higher in pregnant women with GDM than in normal controls. The levels of fasting plasma insulin and plasma glucose levels were (13.18±3.25)mIU/L, (9.13±1.34)mmol/L, whereas the corresponding values in Norman controls were (9.10±3.41)mIU/L (4.72±1.05)mmol/L. The same as the plasma insulin and Glucose levels were significantly higher in pregnant women with GDM than in normal controls. A positive correlation was found between maternal plasma resistin and fasting plasma insulin levels in pregnant women with GDM (r = 0.812, P<0.01), A positive correlation was also found between maternal resistin concentrations and glucose levels in women with GDM (r= 0.573 P<0.01).[Conclusions ]Resistin levels are elevated in pregnant women with GDM compared with healthy pregnant women, a positive levels and fasting insulin levels, as well as between the maternal resistin levels and plasma glucose levels in women with GDM.