The Expression And Meaning Of Melanoma Cell Adhesion Molecule, Matrix Metalloproteinases-Ⅱ And Tumor Suppressor Gene P53 In Mixed Tumor Of Parotid Gland

Object: Determine the expression of melanoma cell adhesion molecule Mel-CAM (CD146 or MUC18), matrix metalloproteinases (MMP-2) and tumor suppressor gene PS3 in normal parotid gland and mixed tumor of parotid gland, and discuss its relation with the stage of mixed tumor of parotid gland.Method: The paraffin-embedded tissue samples used in the study were from the patients of mixed tumor of parotid gland with intact information from January 1983 to January 2003 in Qianfoshan hospital. With more than two years of follow-up, there were 44 benign patients and 39 malignant patients. And there were 30 samples of normal parotid gland collected for study. Two-step immunohistochemical method was used to determine the expression of Mel-CAM, MMP-2 and P53. And its relation with the stage of mixed tumor of parotid gland was analyzed.Result: There are different expressions of Mel-CAM and MMP-2 in normal parotid gland and mixed tumor. There are no expressions of P53 in normal parotid gland; there are different expressions of benign and malignant mixed tumor.Conclusion: It's valuable to determine the expression of Mel-CAM, MMP-2 and P53 for the discrimination of mixed tumor of parotid gland.