Myocardial Ischemia-reperfusion Injury And The Protective Effect Of Lipo PGE₁

A large number of animal experiments and clinical studies have shown that, after the process of myocardial ischemia-reperfusion, sometimes, the myocardial function not only have not been restored, but further aggravated, clinically, some patients present symptoms of arrhythmias, heart failure, cardiogenic shock, multiple organ failure and even sudden cardiac death, which are usually called Myocardial ischemia reperfusion injury (MIRI), the essence of MIRI is severe inflammatory injury. The main mechanism of MIRI is as follows: increased oxygen free radicals, calcium overload, chemotaxis of neutrophil and macrophage, synthesis and release of inflammatory cytokine, energy metabolism disorders, in addition, vascular endothelial cell, nitric oxide, cellular adhesion molecule, apoptosis, no-reflow phenomenon also involved in this process, the interaction of these factors leds to myocardial dysfunction and injury of other organizations [1]. IL-8 is known as the strongest cytokines of selectively neutrophil chemotactic,and its biological activity is closely related to inflammatory response. IL-8 plays an important role in the process of ischemia reperfusion injury, the blood concentration of IL-8 is considered the marks of severity of tissue injury. The increased biological activity of IL-8 is closely related to inflammation, and as a new marker of diagnosis of myocardial ischemia-reperfusion injury. In the process of myocardial ischemia reperfusion, increased plasma ET arising from the release of ET, which caused injury [17,20]. In the process of myocardial ischemia reperfusion, through channels such as: the xanthine oxidase, neutrophil, mitochondria, and self oxidation of catecholamines produce large amounts of oxygen free radicals. Large oxygen free radicals in myocardial cells is one of the important mechanisms of ischemia reperfusion myocardial injury [21]. MDA is the production of radical and biofilm polyunsaturated fatty acids in process of lipid peroxidation, MDA often reflects the level of lipid peroxidation and indirectly reflects the severity of the free radicals's attacking. the process of myocardial ischemia reperfusion can significantly increase the levels of IL-8, ET, MDA, and reduce the activity of SOD, therefore the process has the effect of injury. Finding an drug ,which can effectively prevent and treat of myocardial ischemia reperfusion injury is an urgent problem needs to solve. The Lipo PGE1 not only has traditional prostaglandin E1 features such as expanding vascular to increase microcirculation blood; inhibiting platelet to aggregate, dissolving white thrombus to prevent thrombosis; promoting red blood cell deformation and rigid RBC easily through capillaries to improve microcirculation; through a variety of mechanisms to reduce the free radical, and avoid lipid peroxidation induced by free radicals during the process of reperfusion; compared with the traditional PGE1, Lipo PGE1 is also targeting, sustainability, efficiency, advantages and low side effects, so Lipo PGE1 has more significant advantage. Lipo PGE1 can be used as a new agent to protect myocardial ischemia reperfusion injury.