The Elementary Research Of Diagnosis Of Prostate Cancer Combining Magnetic Resonance Spectroscopy With Prostate Specific Antigen

Objective To analyse the metabolic information of prostate cancer, examinate prostate specific antigen. To evaluate the value of combining magnetic resonance spectroscopy (MRS) with prostate specific antigen in the diagnosis and differential diagnosis of prostate cancer. Methods 69 patients(48 benign prostatic hyperplasia patients and 21 prostate cancer patients)were performed with the scanning of magnetic resonance imaging(MRI)and magnetic resonance spectroscopy (MRS)that have included T1-wighted image and T2-wighted image and chemical shift imaging by Siemens Avanto 1.5T Magmetic Resonance scanner.The serum PSA detection:detection with radio immunoassay.Taken suction venous blood 2ml at between 7 and 8 o'clock preoperative (without 5α-reducase enzyme inhibitor or other endocrine medicine,without manipulating through digital rectal examination),The datum were detected with autokinetic chemoluminescence immunizing set produced by Roche in Japan.The kit was produced by company Abbott in America. After separating the serum. Volume of prostate were detected by B-model ultrasound scanning.Statistical analysis:the numerical data of prostate spectra and the serum PSA were dealed with SPSS 13.0 software.Paint the ROC Curve.Analysed the probability of prostate cancer with discriminant analysis.The means expressed with x±s, compared them with T-test, significant differences was at P<0.05. Results The spectra of PCa and benign prostatic hyperplasia(BPH) were obtained.We got definite signals in each group.The numerical value of (Cho+Cr)/Cit was observed.The average value of benign prostatic hyperplasia(BPH) was 1.1902. The average value of prostate cancer (PCa) was 3.2272. A significant difference exists for(Cho+Cr)/Cit BPH team and PCa team(P=0.001<0.05). Inspecting prostate specific antigen(PSA): In BPH team, the average value of F-PSA:2.434 ng/ml, T-PSA: 13.2856 ng/ml FPSA/TPSA: 0.1987, PSAD: 0.1723. In PCa team, the average value of F-PSA:8.5629 ng/ml, T-PSA:49.5348 ng/ml, FPSA/TPSA: 0.1971, PSAD: 1.2024. There is not significant difference in T-PSA (P= 0.134 >0.05),F-PSA(P=0.202>0.05),FPSA/TPSA(P=0.93>0.05),PSAD (P=0.154>0.05) between BPH team and PCa team.The area of ROC curve between (Cho+Cre)/Cit and pathology was largest ,was 0.780.The value of (Cho+Cre)/Cit was higher than other index in diagnosis.Accuracy rating of diagnosis was high combining magnetic resonance spectroscopy (MRS)with prostate specific antigen and using discriminant analysis. Conclusions 1,Proton MR spectroscopy has made it possible to obtain functional and metabolic information about prostate cancer non-invasively.It is suggests that MRS play a role in the diagnosis and differential diagnosis and the grading and evaluation. 2,Connection MR spectroscopy of prostate with prostate specific antigen(PSA) may improve the accuracy rating in the diagnosis prostate cancer.