Multivariate Analysis Of Prognostic Factors In Patients With Extensive-stage Disease Small Cell Lung Cancer

Objective:Small cell lung cancer (SCLC) represents approximatelyone-quarter of all bronchogenic neoplasms and is characterized by rapid growth and early dissemination. Approximately 60% SCLC patients have extensive stage disease(ED).The aim of this study is to retrospectively review the prognostic factors for extensive-stage SCLC. Methods:From January 2000 to December 2006 , clinical data were collected from 134 patients who had been diagnosed extensive-stage SCLC .The Kaplan-Meier and Cox regression were used analyzed the relationship between the survival after metastasized and prognostic factors of 134 cases of extensive-stage SCLC,such as gender, age, race, KPS, weight loss, pleural effussion, pericardial effusion, superior vena cava syndrome, LDH, tumor markers, anemia, serum-albumin, metastatic location, combination metastasis, number of metastasis, treat method and respose for treatment after metastasize. Results:Univariate analysis indicated that the serum LDH , albumin , anaemia, performance status(KPS), metastasis location ,therapy methods and the efficacy of therapy significantly influenced the survival after metastasized in extensive-stage SCLC(P<0.05). While gender, age, race, pleural effusion, pericardial effusion, superior vena cava syndrome, weight loss, combination metastasis, number of metastasis didn't influence the survival. Multivariate analysis suggested that anaemia ( RR :1.526) , the serum albumin ( RR: 1.485) and LDH( RR :1.464) were the independent prognostic factors of survival. Conclusion:anaemia , the lower serum albumin and the higher LDH are poor prognostic factors for patient's with extensive-stage SCLC.