| Background and ObjectiveIn sub-Saharan African countries, each year malaria devitalize 1 million people lives which is 8 percent of children under five years old, the global have conducted malaria control in 50 years, even though some countries have obtained good results, the malaria epidemic of global trend is still a increasing by traditional anti-malarial global model in the past has been the main vector control, but this measures of the malaria control on the overall results were not ideal, it is very difficult to control malaria epidemic in a short period of time, it is necessary to seek methods that can control malaria a short time, the thesis sum up China' s 30 anti-malarial experience, the fast eliminate malaria by source eradication in the past four years in Cambodia, so we can improved measures on the basis of original anti-malarial eradication methods. Since November 2007 we conduct the fast malaria control methods in the African country (Fast Control of Malaria by Source Elimination), after a few months the implementation of the project, the results of the implementation have obvious progressed than the original method of the results of Cambodia, The new fast malaria control method has promoted global malaria control methods will enable the global malaria epidemic in the form of a fundamental change in a short period of time.Since 2001, artemisinin-based combination therapy have been recommended by WHO as the first line of falciparum malaria medication., has The ACT have been demonstrated its high efficiency, fast efficiency, low toxicity characteristics in different malaria-endemic areas in a short period of years. However, the current trend of global malaria epidemic stills vital. Mainly because it is difficult to cure Plasmodium falciparum malaria gametophyte and the Plasmodium vivax, it is hard to block its spreading, so it can widespread. Between the radical problem of malaria, the problem of curing the P. v is also a difficulty to fast control by source eradication. in this thesis we discuss on how to cure malaria by the source, to be explored achievement of fast malaria control by elimination of the source malaria source.Primaquine mainly cure P. v and kill Plasmodium through inhibition of gametocyte to control malaria transmission, it is the only drugs to cure vivax malaria that WHO recommend treatment is serving adult dose 15 mg /day (0.25 mg/kg. days) 14 days of treatment, but the primaquine has adverse reactions in clinical. The epidemic of Cambodia' s falciparum malaria is relatively common, the team of the China-Cambodia has used a year's time to control malaria, so that the falciparum malaria parasite and morbidity rate have been reduced by the rate of 90% down to a very low level. Between the malaria problem if there is no radical solution to cure the P. v or not we can not completely eliminate malaria, so we can attain purposes that fast control malaria by source eradication. how feasibility of primary use primaquine of 10mg/day dose, orally once daily, with a total period of the treatment eight days course, how about the efficacy and safety of comparison to the P. v patients. If we can prove that the eight days treatment course have the similar efficiency with the WHO recommended course of the 14-day, or even better than 14 days of treatment options and side effects was less than the traditional 14-day treatment courses.The lack rate of G6PD in Cambodia people is 17.1%, Because Primaquine can lead to acute intravascular hemolysis of G6PD deficiency, and even acute renal failure and death. It is great difficulties to cure vivax malaria completely, how to cure this kind of patients without this part of a larger result of hemolysis, and other side effects, so that it does not become a new source of infection for the future, which is now among the radical primary solution to malaria problems. The research topics is designed to use artemisinin plus low-dose primaquine to the vivax malaria patients with G6PD deficiency, and to observe the efficacy and safety of hemolytic degree, and comparison with G6PD normal group, so as to provide adequate information to solve the problem. If it is can be proved that artemisinin plus low-dose primaquine 10 mg / day totally eight days course of treatment methods on G6PD deficiency is effective and safe, even with hemolytic belong to the individual self-limited, the broad masses of Asia and Africa Malaria District on the eradication of malaria, promote accelerated rapidly eliminate sources of anti-malaria, which is the eradication of malaria process will be of great value.
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