Study On Influence Factors And Clinical Characteristic Of Knee Osteoarthritis

Objective:The objective of this study is to explore the difference influence factors of osteoarthritis of knee(KOA)Through a hospital-based case -control study,the results will contribute to the prevention and control of KOA,especially in the south of China.Meanwhile,this study will deepen the understanging of KOA on Traditonal Chinese Medicine(TCM).Methods:In this study we chose the KOA patients as experimental subjects. From June 2007-March 2008,a hospital-based case-control study was conducted in GuangZhou TCM affiliated orthopedics hospital,the case were identified by daily searches Of all inpatient records and pathological report in the wards. All the subjects were interviewed in the hospital by experienced investigators face to face.The Collected data were analyzed using conditional Logisitic Regression Model,computing the cruded and adjusted Odds Ratio(OR)as well as the 95%Confident Interval(CI).Firstly,the univaaiate analysis was used to selected statisticlly significant factors.Then,along with other related factors in terms of specialty,these significant variables were included in the multivariate models based on the plausible risk factors of KOAfrom the literature so as to get the relatively independent influence factors by removing the confounders.Results:A total of 200 subjects were investigated in this study,including 100 patients with KOA,100 in control.The results are as follows:1.Risk factors:Body mass index(BMI)is one of the risk factors of KOA. OR_{23＜BMI＜25}=1.951(95%CI:1.055-3.061),OR_BMI＞25=4.074(95%CI:1.660-10.000), Living buildings without elevators is also risk factors OR=5.500(95% CI:2.239-13.510),Genetic factors is risk factors,OR_two=7.971(95% CI:3.274-19.407),OR_{more than three}=13.333(95%CI:2.389-74.404),Smoking is KOA risk factors.Drinking is KOA risk factors,OR_{1-3 times per month}=2.345(95% CI:1.081-5.089),OR_{every day}=2.549(95%CI:1.052-6.177),Physical Exercise is too frequent is KOA risk factors,OR_{＞two times per week}=2.787(95%CI:1.257-6.182),Bonemineral density(BMD)is KOA risk factors,OR=7.487(95%CI:1.251 -44.812).2.Protective factors:Tea,melons and beans is protective factors,OR_{tea every day}=0.246(95%CI:0.068-0.897).OR_{melon every}day=0.182(95%CI:0.034-0.960)3.Multivariate analysis:risk factors:BMI is one of the risk factors of KOA. OR_{23＜BMI＜25}=3.682(95%CI:1.332-10.178),OR_BMI＞25=8.144(95%CI:2.009 - 33.018), Smoking(＞20/day)is risk factor,OR_＞20/day=13.716(95%CI:1.097-171.487), Drinking is KOA risk factors,OR_{1-3 times per month}=5.116(95%CI:1.295-20.211), Physical Exercise is too frequent is KOA risk factors,OR_{＞two times per week}=28.677 (95%CI:1.591-516.999)。protective factors:Living buildings with elevators is also risk factors,OR=0.047(95%CI:0.003-0.880),Tea and melons are protective factors,OR_tea/day=0.039(95%CI:0.004-0.370),OR_melon/day=0.118 (95%CI:0.014-0.975)。4.Through the 100 cases of KOA patients with clinical characteristics of the image of KOA ISOA KL grading and classification of the related evaluation, the correlation coefficient was 0.371(P＜0.05),statistically significance. Tip knee function classification and grading of images have a certain relevance, were positively correlated.However,the correlation coefficient is less than 0.5,suggesting that correlation is not strong.5.In this study,100 patients with osteoarthritis of the knee for an average bone mineral density 0.807±0.153g/cm²,in accordance with the situation on the image classification analysis of bone mineral density in the group,P＞0.05, with no statistical significance.Conclusion:1.Through non-conditional logistic regression method single factor initial screening out of osteoarthritis of the knee main factors that the main factors influencing factors multi-Conditional Logistic Regression Analysis of Statistics Law was again selected risk factors,protective factors, suspicious or potential influencing factors.1.1 Risk Factors:The study found that residential buildings without elevators, high body mass index,there are two genetic factors in patients with osteoarthritis,drinking habits,exercise more,both to promote the occurrence of knee osteoarthritis. 1.2 Protective factors:The study found that regular tea,regular consumption of fruits and decreased incidence of osteoarthritis of the knee dangerous.1.3 Potential impact of factors:The study found that consumption of soybean products and bone mineral density as osteoarthritis of the knee suspicious factors to be continuing to expand the content samples,and further study.2.Recommendations:This study found that osteoarthritis of the knee disease risk factors exist in life behavior and diet.On the lifestyle through publicity and education,can also be guided by a medical doctor,strengthen self-health awareness,appropriate and reasonable movement,and maintain a healthy way of life,optimistic,positive attitude towards life,and improving the quality of life.For restaurants,and pay attention to balanced nutrition, drinking less,and more tea,regular consumption of fruits and rationally adjust the diet,reduced risk of osteoarthritis of the knee the possibility.3.Through the clinical feature analysis of KOA,we found critique age circa is crinosity stage of KOA,renal deficiency has a close relation with KOA.4.Through statistical analysis of KOA bone density in different imaging class,we can cue there is dependability detween KOA and lumbar degeneration.Alter in bone density may cause by osteophyte.5.Accord to dependability evaluation to KOA ISOA class,KOA K-L class in imageology,peel-flesh-tendon-bone pathogenesis in traditional Chinese medicine and several clinical experiences of my teacher professor hanqinmin.We find during the development of KOA tendious pain is certain stage of KOA,rtheumatism involving bone is the growth of tendious pain.So we can rescan patho-foundation of KOA by the means of tendious pain and deepen recognition KOA.6.By the means of tendious pain,conjug part musculature and bulk differenation of symptoms and signs,more adundance KOA differenation of symptoms and signs system,to guide clinical practice.