Doppler Tissue Imaging In The Estimation Of Left Ventricular End-diastolic Pressure With Coronary Artery Disease

Objective: By Comparing cardiac catheterization ,to study the value of doppler tissue imaging in measuring left ventricular end-diastolic pressure (LVEDP) with coronary artery disease,and to select one not creates valuable doppler parameters for estimating of LVEDP。.Methods: Thirty patients with coronary artery disease carry on Echocardiography and Doppler tissue imaging inspection underwent within 24 hours before cardiac signals from the mural inflow, pulmonary venous inflow, and DTI of the mural annulus were obtained. Invasive measurements of LVEDP were obtained with pig -tailed catheters.Results: Linear regression analysis showed the ratio of mural velocity to early diastolic velocity of the mural annulus (E/E')had the best correlation with LVEDP(S:r=0.825,p<0.01;L: r=0.758, p<0.001).in septal area E/E'≥10 predicted LVEDP≥15 mm Hg with a sensitivity of 87%;a specificity of 82%; in lateral wall E/E'≥10 predicted LVEDP≥15 mmHg with a sensitivity of 82%; a specificity of 89% o the difference in duration between the pulmonary venous A and mural A wave (Pad-Ad) had the better correlation with LVEDP(r=0.753,p<0.001)The duration of the pulmonary venous A wave equalling or exceeding the duration of the mural A wave that means PA d-A d≥0 predicted LVEDP≥15 mmHg with a sensitivity of 79%; a specificity of 81%.Conclusions: The ratio of mural velocity to early diastolic velocity of the mural annulus (E/E')and the difference in duration between the pulmonary venous A and mural A wave provide more valuable parameters for estimating of LVEDP than other methods do. E/E'≥10 and Pad-Ad≥0 may provide a semi-quantitative index for predicting LVEDP≥15 mmHg elevation.