The Study Of Antioxidant Capacity In Patients With Obstructive Sleep Apnea-hypopnea Syndrome

Objective to explore the antioxidant capacity in patients with obstructive sleep apnea-hypopnea syndrome(OSAHS) and impact of continuous positive airway pressure(CPAP) treatment. Method Following polysomnographic examination, 95 sbjucts were assigned to 5 groups: simple snores(16 case), mild OSAHS(11 case), moderate OSAHS(21 case), severe OSAHS(21 case), and control group(26 case). The serum level of superoxide dismutase(SOD),vitamin E(VitE),glutathione peroxidase(GSH-PX),total antioxidant capability(T-AOC) were measured before and after sleep at the polysomnographic examination night. Of 42 patients with moderate or severe OSAHS, 22 patients who underwent nCPAP therapy were set as"nCPAP group", 20 patients who did not undergo nCPAP therapy were set as"control group". 7 patients were excluded from further follow-up. The assessment protocol was then repeated after 3 month,s follow-up. Results (1) There were no statistically significant differences of the serum level of SOD,VitE,GSH-PX,T-AOC between simple snores and control group. The serum level of SOD,VitE,T-AOC were significantly lower in OSAHS patient. The serum level of GSH-PX among 3 groups have no statistically significant differences(F=2.99,p>0.05). (2) The serum level of T-AOC was not different before and after sleep in simple snores and control group. OSAHS patient had less T-AOC after sleep. (3) Liner regression analysis showed the serum level of SOD, VitE ,GSH-PX,T-AOC were negatively correlated with AH(Ir = -0.517 p<0.01;r = -0.717 p<0.01;r = -0.623 p<0.01;r = -0.765 p<0.01). (4) After 3 months nCPAP therapy in OSAHS patients, the serum level of SOD,T-AOC were significantly increased. While there were no similar changes in OSAHS patients without nCPAP therapy. Conclusion OSAHS patients have less antioxidant capacity. Antioxidant capacity was negatively correlated with AHI. Antioxidant capacity could be improved by nCPAP therapy in OSAHS patients.