A Study About Correlation Between VEGF Expression Of NSCLC And PET/CT Imaging

Objective:1.To evaluate the character of ¹⁸F-FDG PET/CT imagingin patients with NSCLC.2.To probe the association betweeen ¹⁸F-FDG absortion and the expression level of VEGF in NSCLC.3.To evaluate the relationship between serum level of VEGF and ¹⁸F-FDG PET/CT imaging.Methods: 1.40 patients were enrolled including 20 squamous cell carcinoma, 14 adeno carcinoma, 4 bronchial alveolar carcinoma and 4 adenosquamous carcinoma ;another,15 patients with benign lesion were enrolled including 8 tuberculoma and 7 inflammatory pseudotumor. All the patients were taken the ¹⁸F-FDG PET/CT imaging of the whole body before operation,then the tumor tissue was obtained after the operation. The VEGF expression status was measured by SABC method, the half-quantitation score of the VEGF expression was taken by mattern analysis.2.40 patients were enrolled including 19 squamous cell carcinoma, 19 adenocarcinoma and 2 bronchial alveolar carcinoma; Another 20 patients with benign lesion were enrolled including 12 tuberculoma,2 pulmonary infection,4 inflammatory pseudotumor and 2 pneumosilicosis.The serum of patients was collected before the ¹⁸F-FDG PET/CT imaging, the srum level of the VEGF examined by ELISA method.Results: 1.The average SUV was significantly higher in patients with NSCLC group than in patients with benign lesion .(p<0.05).2.The half-quantitation score of the VEGF expression have no significantly difference in the squamous cell carcinoma, adenocarcinoma and inflammatory pseudotumor. The score of the VEGF expression was significantly lower in tumor tissue of tuberculoma than in tumor tissue of squamous cell carcinoma and adenocarcinoma.3.There was a significant correlation between VEGF expression of carcinoma tissue and SUV of ¹⁸F-FDG,(r=0.478,P<0.01). Futher more,the score of the VEGF expression was significantly higher in patients with metastasis and/or recurrence after operation than in Patients with no metastasis and/or recurrence.4.The serum level of VEGF was significantly higher in patients with NSCLC than in control group and in patients with benign lesion (P<0.05).5.There was a significant correlation between serum level of VEGF and SUV of ¹⁸F-FDG(r=0.609,P<0.01).6. According to the results of PET/CT imaging. There was a significantly correlation between serum level of VEGF and clinical stage. Conclusion:1.There was a significant correlation between the SUV of ¹⁸F-FDG and VEGF expression of carcinoma tissue, the determination of SUV may be predict clinical value of the vascular proliferation incarcinoma tissue.2.The score of VEGF expression was significantly higher in patients with metastasis and/or recurrence after operation than in Patients with no metastasis and/or recurrence. The score of the VEGF expression may be considered as a screening index of the patients,whether they should recheck or not after operation.3.There was a significant correlation between serum level of VEGFand clinical stage.Serum level of VEGF may be regarded as a prognosticfactor in lung cancer.