The Effects Of The Motor Drugs To The Lower Digestive Canal's Electric Activity Of Sprague-Dawley Rat

Objective: Contriving this experiment to investigate the effects of the domperidone, mosapride, itopride,and clarithromycin to the Sprague-Dawley's ileum and colon's fast wave,and further approach the mechanism of these drugs,thus providing accordings to clinic.Methods: Imbed electrode in the body of the Sprague- Dawley rat,and set up the domperidone group, mosapride group, itopride, clarithromycin group and normal saline control group, using BL-420E to record effects of these drugs to the Sprague- Dawley's ileum and colon's fast wave; then add antagonists :atropine, phentolamine, and propranolol to further approach the mechanism of the motor drugs.Results: 1. Mosapride, itopride,and clarithromycin can raise the amplitude and frequency of the Sprague- Dawley's ileum and colon comparing with before;but domperidone and normal saline can not produce obviously effect on the electric activity to Sprague- Dawley.2. Mosapride, itopride,and clarithromycin can do obviously effect on the amplitude and frequency of the Sprague-Dawley's ileum and colon comparing with normal saline and domperidone,and the itopride is the most notable.There are no difference between mosapride and clarithromycin. Domperidon has no difference to the electric activity comparing with normal saline.3.Atropine can depress the the amplitude and frequency of the Sprague- Dawley's ileum and colon in mosapride, itopride, clarithromycin, and normal saline group;but phentolamine and propranolol can not depress the action of the motor drugs.Conclusion:1. Mosapride,itopride,clarithromycin can raise the amplitude and frequency of the Sprague- Dawley's lower digestive tract.The former is more obvious comparing with the latter.But domperidone has no effect.2. Cholinergic pathway maybe is one of the mechanism of both of mosapride,itopride,clarithromycin; but there are no correlation to adnephrc pathway.