| Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase is a major source of reactive oxygen species (ROS) production in many nonphagocytic cells. Response to the stimulus such as hyperglycemia, hyperlipemia, angiotensinâ…¡and various kinds of cytokines and growth factors, NADPH oxidase could be activited, and produce excessive ROS through the respiratory chain. As a centrol part of the oxidative stress, ROS plays an important role in hemodynamics, matrical reconstitution, tubulointerstitial fibrosis and signal transduction by increasing the advanced glycation end product (AGE) formation, activating the protein kinase C (PKC) and transcription factors(NF-B) pathways in diabetic kidney. Modulation of this enzymatic complex could be a promising step to prevent oxidative stress implicated in renal dysfunction. |
