The Effects And Safety Of Rocal Pulse Therapy Combined With Low Calcium Dialysis In Patients With Secondary Hyperparathyroidism (SHPT) Undergoing Haemodialysis

Objective: To observe the curative effects and safety of Rocal pulse therapy combined with low calcium dialysis in patients with secondary hyperparathyroidism undergoing haemodialysis.Methods: 46 patients were divided into 3 groups according to the level of parathyroid hormone (iPTH). Patients in Group A were with 300pg/dkiPTH≤600 pg/dl, receiving orally Rocal 0.5-1ug, two or three times one week; Patients in Group B were with 600pg/dl1000pg/dl, receiving orally Rocal 2⁴ug, two or three times one week. The pills were taken in the evening after haemodialysis. The concentration of Ca²⁺ in dialysis fluid was 1.25mmol/l. The dosage of Rocal was adjusted based on the level of iPTH. The serum levels of iPTH, alkaline phosphatase (AKP), calcium(Ca²⁺), phosphonoum(P³⁺) and albumin(Alb) were measured at baseline and after therapy.Results: There were no significant difference on serum levels of Ca²⁺, Alb,AKP between baseline and after treatment (P>0.05). The serum levels of P³⁺,Ca×P, iPTH decreased significantly(P<0.05). And the above levels of patientsin Group A or Group B decreased more early and fastly.Conclusion: Rocal pulse therapy combined with low calcium dialysis candecrease the level of iPTH in patients undergoing hemodialysis with secondaryhyperparathyroidism. There was few incidence of hypercalcemia.