The Expression And The Clinical Significance Of CD133/CD44 In The Prostate Cancer Tissues

Objective To investigate the expression of CD133/CD44 in prostate cancer tissues and the clinical significance.Methods CD133/CD44 expressions were detected respectively in the paraffin specimens from 80 patients with prostate cancer according to immunohistochemistrical staining(SABC),and the group of specimens were classified according to Gleason standard and clinical stage.Study the expressions of the two antigens in these specimens by Mickaudie medical digital image analytical system.Analyze the correlation between CD133/CD44 and different Gleason class and clinical stage of prostate cancer apecimens by SPSS medical statistics software.Results There is a large number of CD133 and CD44 brown granules in prostate cancer cell membrane and cytoplasm.Analysis the expressions of CD133,CD44 level group in different Gleason grade and clinical stage prostate via variance test,we found a positive difference statistical significance.It showed positive correlation between CD44,CD133 cells and Gleason pathological levels in linear correlation analysis.In double-staining,CD133 was dyed blue particles and CD44 was dyed brown granules.We found blue CD133 particles in the tumor cells and the membrane, and brown CD44 particles in the cell membrane.It showed positive correlation between CD44~+/CD133~+ cells and the Gleason pathological levels,the clinical stage in analysis of variance test.There is positive correlation between CD44~+/CD133~+ cells with Gleason pathological levels in linear correlation analysis.Conclusion CD133,CD44,CD133/CD44 are all positive correlation with the pathologic grades and clinical significance of prostate cancer;there is a certain extent relevance between the expression of CD133/CD44 in the prostate cancer and hormone dependent prostate cancer,hormone independent prostate cancer.