The Evaluation Of ~1H Magnetic Resonance Spectroscopy In The Ring-enhancing Cerebral Lesions

Purpose To evaluate the value of 1H-MRS in differential diagnosis on high-grade cerebral astrocytomas , solitary metastases and cerebral abscesses.Materials and Methods 43 patients with histological verified(28 cases of high-grade cerebral astrocytomas,6 cases of solitary metastases and 9 cases of cerebral abscesses) were examined with conventional MRI and 1H-MRS before operation by Sienens Sonata 1.5T. Multivoxel 1H–MRS was performed and spectra of three voxels were taken from enhanced-solid part of the lesion, perienhancement region and normal white matter.Fitted areas in the spectrum for NAA, Cho, Cr.Results In multivoxel 1H-MRS from the enhanced-solid part and perienhancement region of high-grade cerebral astrocytomas, the ratios of NAA/Cr, Cho/Cr and NAA/Cho changed significantly by comparing with that of normal control brain tissues. In voxel from enhanced-solid part of the solitary metastases and abscesses, All ratios changed significantly by comparing with that of normal control brain tissues. In voxel from perienhancement region of the solitary metastases and abscesses, All ratios no significant by comparing with that of normal control brain tissues. In voxel from enhanced-solid part of high-grade cerebral astrocytomas,solitary metastases and abscesses, the ratio of Cho/Cr-n was 2.85±0.23,2.79±0.78and1.13±0.08,it was changed significantly by comparing between high-grade cerebral astrocytomas and abscesses, solitary metastases and abscesses. In the perienhancement region the ratios of Cho/Cr changed significantly by comparing between high-grade cerebral astrocytomas(2.25±0.21) and solitary metastases(1.47±0.16), high-grade cerebral astrocytomas(2.25±0.21)and abscesses(1.57±0.15). In the perienhancement region the ratios of NAA/Cho changed significantly by comparing between high-grade cerebral astrocytomas(0.80±0.27) and solitary metastases(1.24±0.17), high-grade cerebral astrocytomas(2.25±0.21)and abscesses(1.22±0.16).Conclusion Combining with routine MRI scan, the ratio of Cho/Cr-n in the enhanced-solid part and the ratios of Cho/Cr and NAA/Cho in the perienhancement region were important to diagnosis intracranial lesions with ring-like enhancement(high-grade cerebral astrocytomas,solitary metastases and abscesses).