The FMRI Study Of Male Schizophrenic Patients With Aggressive Behavior In Resting State

Objective: To explore the differences of function and functional connectivity in resting state between male schizophrenic patients with aggressive behavior(MSA) and male schizophrenia without aggressive behavior(MSNA).Methods: Twenty-three MSA and twenty-four MSNA were collected from forensic patients and inpatients. Demographic characteristics, Scale for Assessment of Negative Symptoms(SANS), Scale for Assessment of Positive Symptoms(SAPS),Barratt Impulsiveness Scale(BIS), Modified Overt Aggression Scale(MAOS) and Early Deviant Family Environment Questionnaire were used to assess the two groups. Thirteen MSA and thirteen MSNA were selected to undergo fMRI in resting state. We choose amygdala as region of interest and analyzed the differences in resting state function and amygdala functional connectivity pattern between the two groups.Results: 1. The scores of the subscale deviant family environment considered by themselves in MSA group were higher than MSNA group, the difference was statistically significant.2. Compared with MSNA, the MSA group had decreased resting state function in bilateral superior frontal gyrus, right middle occipital gyrus, bilateral lingual gyrus, while increased resting state function in right superior temporal gyrus, small region of left temporal lobe and parts of bilateral insula.3. Compared with MSNA, the MSA group had increased functional connectivity in resting state between left amygdala and some regions, they were bilateral middle frontal gyrus, right superior frontal gyrus, right insula, right superior parietal lobule, left inferior occipital gyrus, left anterior lobe of cerebellum, right anterior cingulate. The MSA group had increased functional connectivity in resting state between right amygdala and some regions, they were bilateral superior frontal gyrus, bilateral middle frontal gyrus, bilateral superior temporal gyrus, right middle temporal gyrus, bilateral anterior lobe of cerebellum, left posterior lobe of cerebellum, left lingual gyrus, right inferior parietal lobule, right postcentral gyrus. Only small part of left frontal lobe had decreased functional connectivity with right amygdala in resting state.Conclusions: 1. The results suggest the aggressive behavior of male schizophrenia probably have relations with early deviant family environmental.2. The results show that the MSA group has decreased resting state function in bilateral superior frontal gyrus, right middle occipital gyrus, bilateral lingual gyrus, while increased resting state function in right superior temporal gyrus, small region of left temporal lobe and parts of bilateral insula, which indicates that the aggressive behavior of male schizophrenia probably correlate with dysfunction of the regions mentioned above.3. The results indicate that the amygdala plays an important and complicated role in aggressive behavior of male schizophrenia. The increased functional connectivity in resting state between amygdala and some regions especially superior frontal gyrus and middle frontal gyrus probably correlate with the aggressive behavior of male schizophrenia.