Study Of SerumOPG, SRANKL Concentrations In Patients With Acute Coronary Syndrom

Objective:To determine the serum levels of OPG and sRANKL in patients with acute coronary syndrom(ACS)and estimate the relationship between ACS and the concentrations of OPG and sRANKL.Methods:25 patients with acute coronary syndrome(ACS)and 25 patients with stable angina pectoris were included.Another 25 patients without cronary heart disease(CHD)were selected as control group.All the patients underwent coronary angiography and the Gensini score were used to assess the severity of the coronary stenosis.The levels of OPG and sRANKL in serum were measured by enzyme-linked immunosorbent assay (ELISA).The concentrations of high sensitive C reactive protein(hs-CRP) and low density lipoprotein cholesterol(LDL-C)were also analysed.Result:The levels of OPG were significantly higher in patients with ACS than those of patients with stable angina pectoris and control group (P＜0.01).The levels of sRANKL were obviously decreased in patients with ACS than those of patients with stable angina pectoris and control group(P＜0.01).The levels of OPG in patients with coronary heart disease were positively correlated with the levels of hs-CRP, Gensini score(P＜0.05).The levels of sRANKL and Gensini score, hs-CRP negatively correlated(P＜0.01),and neither were correlated with the concentrations of LDL-C in plasma(P＞0.05).Conclusion:The higher levels of OPG and lower levels of sRANKL in ACS patients,the stronger the inflammatory response in atherosclerotic plaque.Therefore,both of them can indicate the plaque instability.