A Study On The Correlation Between The Apolipoprotein E Polymorphism And Electroencephalogram In Acute Phase After Mild/Moderate Traumatic Brain Injury

Objective To determine the correlation between apolipoprotein E gene(APOE) polymorphism and electroencephlogram of patients with mild/moderate traumatic brain iniury.Methods(1) Venous blood was collected at the time of admission to identify the APOE genotype in 81 patients who presented with mild/moderate traumatic brain injury. APOE polymorphism was identified by PCR—RFLP.(2) All the patients were monitored by electroencephalogram for 2 to 3 times within a week after injury. X2 test and logistic regression analysis via SAS version 8.2 were performed to analyze association of the genotype with electroencephalogram and clinical data.Results(1) Among 81 patients, the distributions of APOE genetypes and alleles matched Haldy—Weinberg Law. (2) The findings of electroencephalogram was significantly different between patients with and without APOEε4 (P<0.05). Ten(62.5%) out of 16 patients with APOEε4 showed an deteriorated electroencephalogram,while only sixteen (24.6%) out of 65 patients without APOEε4 showed it.(3) In 66 patients with stable posttraumatic condition,four (40%) out of 10 patients with APOEε4 showed an aggravated electroencephalogram,while only 7 (12.5%) out of 56 patients without APOEε4 showed it. The ratios of deteriorated electroencephalogram were statistical different between cases with and without APOEε4.(4) Logistic regression analysis showed that APOEε4 was a risk factor to electroencephalogram aggravation after traumatic brain injury.Conclusion(1) APOEε4 is a risk factor of electroencephalogram aggravation during acute stage after mild/moderate traumatic brain injury.(2) The genetic factor is one of factors affecting brain function of patients with traumatic brain injury in the acute phase.