Expression Of Cyclooxygenase-2 In The Recurrence Of Endometriosis After Conservative Surgery

Objective We detect the expression of eyclooxygenase- 2(COX-2)in chocolate cysts of ovary of endometriosis in order to study the significance of COX-2 in the recurrence of endometriosis after conservative surgery.Methods The patients with endometriosis received first conservative surgery were divided into the recurrent group of twenty-five cases and unrecurrent group of twenty-six cases.The control group is of ten simple cysts of ovary.The expression of COX-2 in chocolate cysts of ovary and simple cysts of ovary was all detected by two-step PicTure^TM(PV-6000 ) immunohistochemistry staining methods.Results 1.No positive staining cells were detected in the blank control section.The adenocarcinoma cells of positive control section of colon carcinoma were found positive staining.2.The positive expression of COX-2 was 74.5%in the study group and 30.0%in the control group. The expression of COX-2 in the study group was significantly higher than that in the control group(P =0.0104,P＜0.05).3.The positive expression of COX-2 was 60.0%in recurrent group and 88.46%in the unrecurrent group.The expression of COX - 2 in the unrecurrent group was significantly higher than that in the recurrent group(P=0.0266,P＜0.05).Conclusion 1.The expression of COX-2 showed both higher positive in the recurrent and unrecurrent groups.2.COX-2 overexpression characterized the patients with endometriosis who underwent conservative surgery with lower risk of relapse.3.COX-2 might be involved in the pathogenesis and progress and relapse of endometriosis.4.It may provide theoretical basis of researching on the mechanism of the recurrence of endometriosis in monitoring the expression of COX-2 in pathology specimen after surgery.The study of COX-2 may provide a new idea of clinical treatment to the recurrence of endometriosis.