In the continuing studies on the compounds having new bioactivities structures, we investigated the soft coral Lobophytum sp. and Sesuvium portulacastrum L. collected from Sanya, Hainan Province of China. Twtenty-three compounds were isolated from Lobophytum and Sesuvium portulacastrum L. by repeated column chromatography (CC) on silica gel, preparative thin layer chromatography (PTLC), Sephadex LH-20 and recrystallization. Eighteen structures of these compounds were elucidated by means of spectroscopic methods including 1H NMR,13C NMR,DEPT,1H-1H COSY,HSQC,HMBC,IR,FAB-MS,UV and X-ray. The new compound was screened for its biological activity.Fifteen compounds were isolated from the soft coral Lobophytum sp. in Hainan Province of China. Including a new compound F1, was named Lobophine A and fourteen known compounds. There were three Cembranoids, Sarcophine(F2), Lobohedleolide(F3) and 7Z-lobohedleolide(F4). Six steroid compounds, Gorgosterol (F5), Campester(F6), Lobophytol(F7), Cholesterol(F8), Ergosta-5, 24(28)-dien-3β-ol(F9), and (22E,24R)-5α, 8α-epidioxyergosta-6, 22-dien-β-ol(F10); Two fatty compounds, Cetyl alcohol(F12) and Palmic acid(F13). Batylalcohol(F11). di-iso-butyl o-phthalate(F14) and di-(2-ethyl)-hexyl o-phalate(F15). The new compound F1 was screened for it's biological activity. At the same time we get the single crystal structure of F2, and definite it crystal configuration by X-ray diffraction.Four compounds were isolated from the the Sesuvium portulacastrum L. in Nanhai of China. Three of them were defind as Ecdysterone(H1), Corosolic acid(H2), Daucosterol(H3). The compound structure of H4 was not defined.
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