| Morus nigra belonds to the genus Morus of the family Moraceae, distributed in the XinJiang Province.M.alba is a kind of Chinese traditional medicine,which was first recorded in Shengnong Bencao Jing, and its barks,branches,leaves and fruit can be used as traditional Chinese medicine.The genus Morushas sixteen species in the world,eleven of them grow in many provinces of China.The chemical constituents of morus were focus on M.alba,M.australis,M.mongolica,M.bombycis,M.lhou,M. insignis et al.Until now,there were no such reports on M.nigra.Its constituents were main]y flavone,stilbene and benzofuran derivatives and these compounds had hypotensive,antibiotics,hypoglycemic and antivirus activities.In order to search antihypertension,antivirus,antibacterial, antifungi,antioxidation,antiinflammation,and anticancer activities compounds,the chemical constituents of the barks of M.nigra were carefully studied.About 31 compounds were isolated,they were Mornigrol A(1)*, Mornigrol B(2)*,Mornigrol C(3)*,Mornigrol D(4)*,Mornigrol E (5)*,Mornigrol F(6)*,Mornigrol G(7)*,Mornigrol H(8)*,Oleanolic acid(9),Ursolic acid(10),Methyl Oleanolate(11),Octadecyl(E)-Ferulate (12),Octacosyl(E)-Ferulate(13),β-sitosterol(14),Morusin(15), Cyclomurosin(16),Kuwanon C(17),Cyclocommunol(18),Dihydrokaempferol (19),Norartocarpetin(20),Apingenin(21),Quercetin(22),Albafuran A(23), Albanin A(24),Albanin E(25),Oxyresveratrol(26),Moracin M(27), Albafuran B(28),Mulberofuran L(29),Albafuran C(30),Daucosterol(31).1-8 were the new compounds.12 and 13 were isolated from the genus Morus and the plant for the first time.Other thirtyteen compounds(9,11,18,19, 21-25,27-29,31) were isolated from M.nigra for the first time.Their structures were mainly elucidated by spectroscopic evidence,such as MS, NMR,UV,IR and chemical methods.The results of bioassays displayed;(1) Albafuran A,Albafuran B, Mornigrol D,Albafuran C,Mulberofuran L from the EtOAc soluble part of nigra,inhibited the production of the lipid peroxide induced by Fe2+-Cys system in the Liver microsomes LPO obviously,with inhibitory rates more than 50%at a concentrate of 10-5mol/L.(2) On the pharmacological model of release ofβ-glucuronidase from rat PMNs induced by PAF,three compounds Albanin A,Mornigrol C and Mornigrol D,isolated from K nigra,were revealed the anti-inflammation activity with the inhibitory rates more than 50%at a concentration of 10-5mol/L.
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