Calcium Sulfate As Bone Graft Material Loaded With Antibiotics

Calcium Sulfate, as a common used implanting material, shows good biocompatibility, biodegradability, osteoconductivity and mechanical property. The studies about using calcium sulfate as repairing fillers for the treatment of bone defection are reported now and then, but the fabrication of injectable implant was hardly studied. In this text, calcium sulfate hemihydrate, as the basic material, was incorporated with nuclei, cellulose derivatives, surface modifier and drugs, to form injectable bone filler loaded with drugs. The two best ratios of the materials (OL-1 and OL-2) for biocompatibility are studied, and research results show that OL-1 filler do not exhibited deleterious effect on cell viability. In the animal text all tested animals do not exhibit poisoning symptoms in infected bone defects in the use of pre-trial OL-1 as the implantation of materials, and in 20 weeks after implantation we find that two thirds of the bone defect observed through X-ray has been healed. The test results prove that such injectable filler loaded with the drug for the treatment of bone defects play a positive role in healing.In addition, calcium sulfate loaded the drug for open surgery is more common in the study. Many studies show that rapid absorption of such material exists and the release of the drug is two quick. In this paper calcium sulfate beads loaded with drugs were prepared in the models. Different kinds of materials were modified on the surface of the beads to extend the degradation and the drug release. The results show that with good biocompatibility polylactic acid-glycolic acid (PLGA) for coating materials, incorporated with different pore agent to prepare in-situ hole beaded surface coating materials, coating materials obviously slow down the degradation. The degradation time of the materials has been extended from 30 days to around 60-90 days. Drug release study shows that the drug release rate of all coated materials is significantly reduced, and their release time is over 50 days. While that of the uncoated materials is less than 30 days.