| Peptic ulcer(PU)is chronic ulcer ,which main happens on stomach and duodenum , the concept come form gastric acid and pepsin have digestion on membrane that participate in the emerge of ulcerative . It is one of the common disease , various kinds factor like be infected with HP,medicine,heredity and social psychic factor, all of them can induce or promote this disease happen . This disease's clinical manifestation is different , partial patient may absence of symptoms ,but multiple PU have chronic course of disease , periodic episode , rhythmical allay characteristic . Clinically, duodenal ulcer than gastric ulcer found. Ratio between the two is about 1.56-5.6:1. Ulcer seems more common in middle-aged and older, while the middle-aged patients with gastric ulcer, the ulcer recurrence has become troubled, the entire course of an average of 6-7 years, some for up to 10-20 years or even longer. Therefore, the treatment of peptic ulcer is one of the world communities to digest one of the hot issues.About the pathogenesis of gastric ulcer more complicated over the past two decades, the pathogenesis of ulcer disease gradually clear, following the concept of a consensus has been reached: peptic ulcer are caused by a variety of causes of the heterogeneity of the disease group; Antacids and suppression acid drugs for the treatment of peptic ulcer; Hp eradication can significantly reduce the ulcer recurrence rate. Studies have now pointed out that the nerve-endocrine- immune network (NEI) in ulcer formation and treatment has an important role. Chinese medicine theory to five internal organs as the central link between the organs, blood and the body constitute a yin and yang, balance organs function; Both starting from the overall. A large number of animal experiments and clinical data have proven that the body through the nerves - endocrine - immune network (NEI) regulating mechanism nervous, endocrine, immune system function have an impact, while also the interaction between them, which is the overall concept of Chinese medicine with consistency. Residing in the spleen and stomach coke, Qualcomm tune up and down, in the coordination of five internal organs'air-tune in order to maintain the normal activities of mind plays an important role in the central shaft, spleen and stomach function is normal human air-tune Chang, gas machine body are important changes in physiological or pathological response . This shows that peptic ulcer affects the whole body of the regulation and control mechanisms.Organs according to practitioner of Chinese medicine syndrome differen- tiation theory, the pathogenesis of peptic ulcer core focus on the liver, spleen, stomach three dirty. Medicine of Chinese understanding of ulcer disease is the main weak spleen and stomach,treatment by bupijianwei mainly still are important methods of the undeniable. Professor of my department by the side of ancient "Huangqi Jianzhong tang" ( "jinkuiyaolue"), based on clinical practice over a long period, addition and subtraction to be WWY, the treatment of each in cold, tiredness stomach pain after attack secret anguish, pain of empty stomach, minus the pain to eat, vomiting water, reduce drink and food, or limbs not temperature, thin runny stool for the performance of the spleen and stomach in patients with cold-based clinical practice to obtain the exact effect. Of such patients in the drug played a warm and cold-dispelling, the effect of spleen and stomach. This experiment we have chosen to cold diarrhea and the production of acetic acid smear method of animal models, For the spleen and stomach ulcer cold cards, neuropeptide from Gastrointestinal side stomach drink temperature reveals the mechanism of clinical efficacy.Experiments we have chosen healthy adult Wistar rats as research subjects were randomly divided into five groups, namely normal control group, model control group, the WWY drink high-dose group, the WWY drink low-dose group, ranitidine group. Use bitter cold and rush down to set up the deficiency cold of the spleen, then coated with the modified acid Okabe act set up a rat model of gastric ulcer. By observing the general state of rats such as weight, diet, mental health, hair, action and reaction to determine the success of the model set up. Experimental process of the health of the general growth of the control group of rats in good condition, and the model began to emerge weight loss in rats. The third day of eating rat model reduced drink and food, abdominal distension, it runny, stool color shallow, but still forming, increasing urine output and weight loss; the fourth day, rats make them apathetic, chills, then Greed , weight loss, decreased activity, color haggard; the fifth day, the spirit of the model rats were apathetic coat dry draft, End Valley is not, and weight decreased significantly, action slow, slow response; Sixth day, with the exception of the healthy control group, all rats were not end valley, and vertical hair, toxo-shoulder, curled, abdominal distension, increased urine output; the seventh day, rats not only the above symptoms, but also turn a blind eye, the spirit of low even heavier, and some have been rectocele rats, rats swimming in cold water to shorten the time, suggesting that the capacity of its cold gradually declining. 9th day of applying law to give acetic acid model, rats toxo- shoulder, abdominal distension and slow performance. WWY administration two weeks after high-dose group and the ranitidine group of animals from curled, erect hair, atrophy, abdominal disten- sion and then the gradual improvement of Greed. Low-dose group and model group, poor performance, but more of a good pre-operative activities. The fourth week after administration, high-dose group of animals will no longer Tong, abdominal distension and more active, but the weight did not change significantly; ranitidine group still distention, it runny, no significant changes in body weight; the end of the experiment when the high-dose group and the healthy control group, no significant general status was no significant difference; Ranitidine was no abdominal distension, it runny, but weighs less compared with the normal group; low-dose group still distension, it runny, no significant changes in body weight; the model group of animals is still low, curled, erect hair, then Greed, weight loss.This experiment, the experimental rats by detecting gastric acidity, gastric tissue CGRP content in plasma and pituitary and brain regions in NT content of MIT to reveal acid and gastrointestinal neuropeptides on the effects of gastric ulcer, at the same time from the perspective of gastrointestinal neuropeptide research temperature treatment of gastric ulcer mechanism drink. CGRP has to improve gastric mucosal blood flow, reduce gastric acid secretion, inhibit gastric motility and to stimulate somatostatin release and other functions. Research has shown that CGRP on the release of gastrointestinal hormones and gastrointestinal function play an important regulatory function, low levels of CGRP may be a factor. WWY by regulating the treatment of gastric ulcer CGRP may have two points: first regulation of neuroendocrine disorders, so that the normal neuroendocrine function, the release of sufficient quantities of CGRP, thereby inhibiting gastric acid secretion, increasing gastric mucosal blood flow and improve the gastric mucosa of ischemia, hypoxia; second is through the NEI system stimulation on capsaicin-sensitive sensory neurons, induced by these nerve excitability, causing the release of CGRP. NT inhibit gastric acid secretion and gastrointestinal motility and stimulate the pancreatic juice and pancreatic polypeptide secretion, with the nutritional function of the gastrointestinal tract mucosa, the occurrence of disease in the digestive system, plays an important role in development. This experiment concluded that the lower level of plasma NT, NT pituitary in the higher level, the weaker inhibition of gastric acid, gastric mucosal protective effects have also weakened. For whether there is any relationship between the need for further study. MIT as an important brain-gut peptides and gastrointestinal hormone, mainly involved in gastroin- testinal motility and secretion of certain digestive conditioning, this experi- ment prompted the central motilin as an important brain-gut peptides and gastroin- testinal hormones on gastrointestinal motility and secretion of digestive juice with some important physiological significance, may be involved in gastric mucosal cells in the protective effect of regulation, but motilin ways affect the digestive juice secretion and gastric mucosal protection is not clear yet in further depth. The results showed: body weight in rats after model than model significantly reduced after treatment of rat body weight gradually increased, in order to model the lowest increase in the control group, while the temperature of stomach drink high-dose group the highest rate of weight gain. After treatment of gastric ulcer in rat gastric tissue CGRP increased, reached a healthy control group; plasma NT increased NT content in the pituitary is decreasing; various brain regions to reduce MIT. Stomach can drink temperature by regulating the levels of gastrointestinal neuropeptides in order to exert its antiulcer effect, which warm the stomach to drink cold in the spleen and stomach ulcer type of clinical treatment provided an important experimental basis.To sum up:â‘ nerve - endocrine - immune network is a very fine network-conditioning systems, the body may pass the three major network systems to achieve stability within the environment and the protection of the purpose of defense.â‘¡gastrointestinal hormone have neuroactive substances, plays a neurotransmitter,neuromodulator and hormonal role in neuroendocrine or paracrine manner to participate in neural information transfer, regulation, including development, nutrition, differ- entiation, proliferation and wither functional activities, such as death.â‘¢WWY rise of rat stomach drink through the stomach tissue CGRP, plasma NT, reduced pituitary NT, the MIT brain regions to regulate gastrointestinal neuropeptide levels. This shows that temperature may be the stomach drinking by regulating gastrointestinal neuropeptides and exert antiulcer effects, which warm the stomach to drink cold in the spleen and stomach ulcer type of clinical treatment provided new experimental evidence.
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