The Expression Of VEGF-C, VEGFR-3mRNA And Its Predictive Study On Lymph Node Metastasis And Prognosis Of Non-small Cell Lung Carcinoma(NSCLC)

Objective Vascular endothelial growth factor C(VEGF-C) and vascular endothelial growth factor receptor 3(VEGFR-3) play important roles in lymphangiogenesis of malignant tumors;their expression are closely related to lymphatic matastasis and prognosis of malignant tumors. This study was designed to investigate the expression and clinical significance of VEGF-C and VEGFR-3 in non-small cell lung carcinoma.Method The expression of VEGF-C and VEGFR-3mRNA was examined by RT-PCR in 60 cases of the fresh non-small-cell lung cancer tissues and normal lung tissues,followed by the further analysis on the relationship between VEGF-C/ VEGFR-3mRNA expression and clinical-pathological characters.Result VEGF-CmRNA was detected in 41 of 60(68.33%) lung cancer tissues, and VEGFR-3mRNA expressed in 34 cases of the VEGF-CmRNA positive tissues. There was a statistically positive correlation between the incidence of VEGF-C and VEGFR-3mRNA(p<0.01). The expression of VEGF-CmRNA was significantly associated with the differentiation,TNM grate and lymph node metastasis(P<0.05,P<0.01, respectively), but not to the patientage,tumor size or pathological type. The expression of VEGF-C / VEGFR-3mRNA in normal lung tissues under detectable level.Conclusion The expression of VEGF-C and VEGFR-3mRNA are closely related to lymphatic matastasis and prognosis of lung cancer.