Expression And Clinical Significance Of Fas, FasL, And Bcl-2 In Non-small Cell Lung Cancer

Objective To explore the expression and clinical significance of Fas,FasL and Bcl-2 in non-small cell lung cancer.Methods EnVison immunohistochemical method was used to study the expression of Fas,FasL and Bcl-2 in 60 cases of non-small cell lung cancer and adjcent normal lung tissue..Results1.The expression of Fas in non-small cell lung cancer(NSCIC) weaken apparently campare with adjcent normal lung tissue,and positive expression rates are 100%,62.5%and 46.4%in adjcent normal lung tissue, squamous cell carcinomas and adenocacinomas respectively.The expression of FasL in non-small cell lung cancer(NSCIC) enhanced apprently campare with adjcent normal lung tissue,and positive expression rates are 22%,65.6%and 71.4%in adjcent normal lung tissue,squamous cell carcinomas and adenocacinomas respectively.2.The expression of Bcl-2 in non-small cell lung cancer(NSCIC) enhanced apprently campare with adjcent normal lung tissue,and positive expression rates are 16.7%,68.8%and 53.6%in adjcent normal lung tissue,squamous cell carcinomas and adenocacinomas respectively.3.Expression of Fas,FasL and Bcl-2 are correlated with NSCLC's TNM stages,differentiation and lymphatic metastasis.Expression of Fas weaken in late stage, lower differentiation and lymphatic metastasis cases,and their positive expression decrease,however,Expression of FasL and Bcl-2 are on the contrary.Conclusion The expression imbalance of Fas,FasL and Bcl-2 is closely associated with non-small cell lung cancer..