| Objective: To study the effect of Valsartan on the expression of monocyte chemoattractant protein-1(MCP-1) and peroxisome proliferator activated receptor gamma (PPARγ) in experimental atherosclerotic rabbits.Methods: Twenty four male New Zealand rabbits were randomly divided into 3 group : group 1: normal rabbit chow, group 2: cholesterol diet, group 3: cholesterol diet supplemented by Valsartan. All rabbits were fed according to experiment design for 12 weeks. Blood samples were obtained from vein for detection of serum lipid. The intima-media thickness was measured. The expression of MCP-1 and PPARγwere examined by immunohistochemistry and reverse transcription polymerase chain reaction.Results: Levels of serum TC,TG,LDL-C in group 2 and 3 were significant higher than those of group 1(P<0.05), but it has no significant difference between group 2 and 3 (P>0.05). The ratio of intima-media reduced obviously in group 3 than those of group 2 (P<0.05). The expression of MCP-1 was higher in group 2 than group 1 and group3 (P<0.05). The expression of PPARγwas higher in group 3 than group 2(P< 0.05). Conclusion: These findings suggest that Valsartan could affect atherosclerosis and the MCP-1 expression in experimental atherosclerotic rabbits which are probably related to its activating effect of PPARγ.
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