Anticancer Activity Screening Of Diverse Small Molecules Libraries And Related Mechanisms Research

Malignancy is one of the major diseases to cause actual harm to the health of people. As we know, the cancer etiology is intricate and drug resistance exists in malignancy, it is very difficult to clarify the pathogenesis of malignancy and cure this disease. Compounds in diverse small molecules libraries were used as small molecular probes to screen for anti-cancer compounds.Nowadays, the studies of potential targets for anti-cancer drugs were progressing fast, just like protein kinase B (PKB), aromatizing enzymes and cyclin-dependent kinases (CDKs). And the cell-cycle check point was paid more attention as a potential targets for therapy of cancer. Inhibitors of CDKs can potently arrest the cell cycle progression and repress the proliferation of cancer cells, it is of great significance to improve curative effects of anti-cancer drugs and develop new compounds for cancer therapy.In present study, we screened the anti-cancer activity of 74 compounds on 5 different cancer cell lines and then a further study was made for the mechanisms of XJW20 potent effects on proliferation of human leukemia cell line K562.