Preparation And Characterization Of Bio-Polymer Material Modified By Phosphorylcholine

Biomedical polymer materials can be used as artificial organ or tissue. And when they are replanted into body as substitutes, blood compatibility should be considered. It is attributed to significant responses that thrombus and thrombogenicity occurs. Hence, biocompatibility should be enhanced to prevent thrombus by modification. Phosphorylcholine analogous polymers have good blood compatibility, and have been abroadly used in biomaterials modification field.In this reation, poly(L-lactic acid)-phosphorylcholine(PLA-PC) which has good biocompatibility has been synthesized in the special condition. FTIR, XPS and 1H-NMR were employed to confirm its chemical structure and the synthetical method. DSC and Dynamic-contact-angle (DCA) were performed to analyze thermal and hydrophilic properties. The results demonstrated that the contact angle between PLA-PC and water has declined to 78.50°. And surface energy has increased to 51.03mN/m, which means that hydrophilic property of PLA has increased. The results also revealed that the content of PC would increase much more when molecular weight of PLA was small; and the molecular weight of PLA would affect the content of PC significantly when molecular weight of PLA was smaller.Chitosan-phosphorylcholine(CTS-PC) has been synthesized in the same condition above. Then FTIR, XPS and 1H-NMR measurements were also carried to confirm its chemical structure and the synthetical method. The results of XPS demonstrated that the content of PC would be less when molecular of Chitosan was larger. And the molecular weight of Chitosan after reaction has declined slightly.