Study On The Drug Release Kinetics Of Films Of Konjac Glucomannan-Xanthan Mixtures

In this paper, Konjac Glucomannan (KGM) - Xanthan Gum (XG) blending hydrogel is taken as the object of study; Using the vitro release evaluation devices, the drug release through KGM-XG films in colon simulation solutions is tested; The drug release speed factors are inspected; The drug release rules are discussed; The polysaccharide interaction and hydrogel structure are analyzed by using scanning electron microscopy (SEM), differential scanning calorimetry (DSC) and atomic force microscope (AFM). Based on the above results, with appropriate assumptions and descriptions of the drug release process, the drug release kinetics models are set up; The equation fitting and the parameter discussion are carried on. Main results are as follows:The drug release rules through KGM-XG polysaccharide blend films: With absence ofβ-mannanase in release solutions, the drug release is steady process; With presence ofβ-mannanase in release solutions, the drug release speed increases along with increasing time; The drug release speed improves when the enzyme density, the film degeneration degree and the model drug solubility increases and reduces when the film thickness, the KGM:XG proportion and the model drug molecular weight increases.Scanning electron microscopy (SEM) observations show that with the blend films swelling 1~6 hours, the internal structure remaines stable; Because of the degradation interaction ofβ-mannanase, the film will relax and have further erosion as the enzyme density and the degeneration time increases; Differential scanning calorimetry (DSC) analysises show that KGM and XG has the obvious hydrogen bond interaction; The hydrogel thermal stability improves and the enzymolysis responsiveness reduces when the KGM content reduces; Atomic force microscope (AFM ) observes that the basic structure unit of hydrogel is the "Y"-shaped unit, with which a three-dimensional network structure is formed.The drug release kinetics equation in release solutions with absence ofβ-mannanase is:In release solutions with presence ofβ-mannanase, the self-degradation drug release kinetics equation and the enzymatic drug release kinetics equation are: The above equations are demonstrated in good agreement with the experimental results.