The Functional Magnetic Resonance Imaging Study Of Chronic Depression In Resting State

Objective:Using functional magnetic resonance imaging(fMRI)and regional homogeneity(ReHo)analysis,we explored differences of regional brain spontaneous activity in resting state in chronic depression vs healthy participants.The purpose was to investigate the baseline character of neural activity in chronic depression associated with physiological changes or affect disorder.Method:10 cases of disease more than 3 years in patients with chronic depression and 10 healthy controls in the resting state of brain functional magnetic resonance (fMRI)scanning.We used Hamilton Depression Rating Scale(HAMD)to assess the severity of symptoms and use SPM2 software and RESTing-state fMRI data analysis toolkit software to analyze data from the image processing.Results:1.Abnormal spontaneous ReHo of left corpus callosum,right lentiform nucleus,right putamen,claustrum,right frontal lobe,right cerebellum posterior lobecerebellar tonsil,right cerebellum posterior lobe-inferior semi-lunar lobule,right brainstem,left brainstem-lentiform,medial globus pallidus was significantly increased in resting state in depression compared to healthy control.2.Abnormal spontaneous ReHo of right inferior parietal lobule,right parahippocampa gyrus,left occipital lobe lingual gyrus,cerebellum anterior lobe,right brainstem midbrain,left brainstem midbrain was significantly decreased in resting state in depression compared to healthy control.Conclusions:By using ReHo method and resting fMRI,the abnormal spontaneous activity in the left corpus callosum,right lentiform nucleus,right putamen,claustrum, right frontal lobe,right cerebellum posterior lobe-cerebellar tonsil,right cerebellum posterior lobe-inferior semi-lunar lobule,right cerebrum was significantly increased; right inferior parietal lobule,right parahippocampa gyrus,left occipital lobe lingual gyms,cerebellum anterior lobe,right brainstem midbrain,left brainstem midbrain was significantly decreased was found as references for distinct brain activity signatures in chronic depression.3.The neural basis of Chronic depression affective disorder are brain dysfunction in brain stem,cerebellum,basal ganlia.