The Protective Effective Of L-carnitine On Experimental Hepatic Injury

Objective To investigate the protective effective and possible mechanism of L—carnitine on experimental chronic hepatic injury rats induced by CCl₄ on experimental acute hepatic injury rats and mice induced by CCl₄ and on experimental acute hepatic injury mice induced by alcohol and APAP.Metheds To duplicate the chronic liver injury models of the rats induced by CCl₄,the acute liver injury models of the rats and mice induced by CCl₄,the acute liver injury models of mice induced by alcohol;and APAP respectively. To divide the rats and mice into different groups at random according to their weight: normal groups,model groups,medicine groups and LC groups(the doses and groups were diffrent according to the diffrent models).To give the CCl₄ or alcohol or APAP to duplicate the models,and determin the values of ALT,AST,T-BIL,TP,ALB,A/G,calculate the liver indexes,detect pathologic change of the chronic liver injury models of the rats induced by CCl₄.To detect the contents of protein and the activities of SOD,MDA,GSH-px,T-AOC,CAT.Results Duplicate the models successfully.As for the the chronic liver injury models of the rats induced by CCl₄,LC of 0.15g·kg^-1 doses can reduce the values of ALT,AST,liver index(LI),T-BIL,TP,ALB and A/G remarkably(P＜0.01),and lessen the pathologic change of hepatic tissue injuried by CCl₄ efficiently.As for the acute liver injury models of the rats and mice induced by CCl₄,the acute liver injury models of mice induced by the alcohol;and by the APAP,the values of LT,AST,LI reduced remarkably,and present dose dependent.(P＜0.05,P＜0.01);but as for the acute liver injury models of mice induced by the alcohol,the values of LI were not statistically significant.(P＞0.05)..And the activities of SOD,GSH-px,CAT,T-AOC increaced significantly(P＜0.05,P＜0.01),while the activity of MDA reduced(P＜0.05,P＜0.01).and presented dose dependent.Conclusion LC has a remarkably protective effect on chronic liver injury rats induced by CCl₄,on acute liver injury rats and mice induced by CCl₄,and on experimental acute hepatic injury mice induced by alcohol.and APAP.The protective mechanism relates to the antioxygen property of LC.