Analysis Of Clinical Characteristics In 32 Patients With Cranial Venous Sinus Thrombosis

OBJECT:To discuss the Clinical characteristics of patients with cranial venous sinus thrombosis.METHOD:We retrospectively evaluated the data of 32 patients with cranial venous sinus thrombosis(CVST) who were admitted to our hospital during the years from 2004 to 2008.All the patients with cranial venous sinus thrombosis were diagnosed by computed tomography(CT),magnetic resonance image(MRI),or digital subtraction angiography(DSA).Then we discuss the pathogeny,the major symptoms and physical signs,treatment of CVST,and the influential factors of prognosis furtherly.RESULT:Among the 32 patients,there was a man predominance with a man to female ratio of 1.29 to 1(14 female,18 men).The age range was from 15 to 67 years old with an average age of 36.41±0.60 years.There are 21 patients with acute symptom onset,while 4 patients with subacute symptom onset,and 7 ones with chronic symptom onset.The most common pathogeny was infection(8 cases,25%),While the pathogeny of 13 patients was uncertain;there are 24 patients(56.3%) with multiple cranial venous sinus thrombosis(the amount of embolism≥2),while 8 patients with single cranial venous sinus thrombosis.The more amount of embolism was,the severer clinical symptom was;the predilection sites cranial venous sinus thrombosis were sigmoid sinus and transverse sinuses;and 18 patients complicated with the impairment in the parenchyma of cerebra such as cerebral infarction and intracerebral hemorrhage.Among the 18 patients who were treated with low molecular weight heparin base based on the based on the routine treatment,17 ones had the good prognosis;While there were only 8 cases with good prognosis among the 14 patients who were treated with routine treatment only.The differece between the prognosis of the two groups is significant(P＜0.05).CONCLUTION:1.Among the CVST patients,the youths were more liability to the disease.The course of disease with acute symptom was more common.2.Among the CVST patients,the most common pathogeny was infection 3.Multiple cranial venous sinus thrombosis was more common;the predilection sites cranial venous sinus thrombosis were sigmoid sinus and transverse sinuses,and then superior sagittal sinus;4.The first and main clinical symptom was cephalea 5.Treated with low molecular weight heparin base based on the based on the routine treatment got satisfactory prognosis.