Relationship Between Arginine Vasopressin And Heart Failure

Heart failure is the final pathway for myriad diseases that affect the heart and a major cause of a series of cardiovascular mortality. The activation of neurohormones is the core in the progress of heart failure and some of these neurohormones play a pivotal role in the pathophysiology of heart faillure. Arginine vasopressin (AVP) is one of these most important neurohor -mones. Activation of carotid baroreceptors has been implicated in the synthesis and release of AVP during arterial underfilling in patients associated with heart failure. AVP affects pathophysiology of heart failure by causing vasoconstriction, contributing potentially to remodeling of the left ventricle and deteriorating fluid retention and worsening of hyponatremia. Based on data from available clinical trials, we can conclude that vasopressin antagonists will offer a new treatment option for patients with congestive heart failure.