Study On The Preparation Of The Properties Of β-TCP/UPPE Used As A Potential Injectable Bone Repair Material

Periodontal diseases happen frequently in all kings of mouth diseases. At present, doctors in China filled irregularly shaped defects of alveolar bone caused by periodontal diseases by importing injectable bone repair biomaterials with high iatric cost.Unsaturated polyphosphoester(UPPE) possess good biocompatibility ,injectablity and can be solidified. but its mechanics can't reach the require of alveolar bone repair biomaterials, and its solidify temperature was too high.β-tricalcium phosphate (β-TCP) possessed excellent biology Performance. After being compounded with UPPE. The mechanical properties of UPPE was enhanced.So we prepared theβ-TCP/UPPE composite studied on its performances,discussed its application in alveolar bone repairation field.First of all, This study compared the first H3PO4/Ca (OH) 2 system in response to the order of feeding the impact of the product and found that drop H3PO4 into Ca(OH) 2 can get pure precursor product after being calcined can get high purityβ-TCP. So we choose this method to getβ-TCP and do the research on it. The phase, composition and morphology of the product getting through this method were characterized, and also the feed rate, temperature solution, calcination temperature were inspected the impact of particle size and the product phase.We evaluated the cell toxicity and the load capacity of tetracycline hydrochloride of theβ-TCP.The cytotoxic laboratory experiments showed that theβ-TCP is non-cytotoxic, and is absolutely a qualified biological materials.The experimental results show that the loading capacity of theβ-TCP calcined at 1000℃is better than that at 800℃.Compounded theβ-TCP powder with UPPE according to the different proportion ,used the formyl peroxide (BPO) / N, N-2-methyl-aniline (DMT) as the initiator, N-ethylene Pyrrolidone (NVP) as a cross-linker, NaCl as pore preparation ofβ-TCP / UPPE composite materials. testing the system viscosity. without initiator Found that the effect ofβ-TCP powder on the viscosity of system is more complicated. Put cured composite materials in the immersion of the body simulation (SBF), at constant temperature bath shake the bed,for vitro degradation test. Test weight loss, strength, for scanning electron microscopy (SEM) observation.β-TCP found on the mechanical properties of complex systems from the enhanced role, and can reduce the material in the process of degradation and weight loss, while improving the mechanical stability. Through regulation and UPPE/β-TCP to regulate the content of the performance of composite materials.