| Ultrasound is one of the ways which is firstly used to make differential diagnoses of nodule in liver. In some cases, the grey image of ultrasound can not identify the nodule in liver because the characteristics of HCC and hemangioma in ultrasound image are very similar. Since CDFI has been used in clinical work, the CDFI has the ability to reflect the veins of the tissue and helps to identify nodules in liver. However, the CDFI is limited in some cases. With the development of the ultrasound, the contrast-enhanced ultrasound (ECUS) is becoming more and more important, which is a new way to make diagnoses in FLL.Some reports show that the feature of ECUS of HCC is very typical, which is fast enhancement during the arterial phase and fade away during the portal venous phase and low echo in the delayed phase. This situation is called "fast in fast out". However, the features of some cases of HCC are not like that, which is hard to distinguish them from the benign tumors. Haemangioma is one of the benign tumors, which is often found in liver. The reason of the haemangioma is the malformation of the vein. The incidence of the disease is from 0.35% to 2%. Constrast-enhanced ultrasound can show the mode of the blood supply and the vessel in the tumors by the contrast-enhance ultrasound. Based on the structure of the vessel of the tumor, the differentiation of the tumor can be offered.Objective: to evaluate the clinical application of contrast-enhanced ultrasound to identify nodules in liver.Methods: 57 patients were enrolled between September 2006 and September 2007. There were totally 65 nodules in liver by ultrasound. The patients underwent CEUS and lesion-targeted US guided biopsy successively on the same day. The parameters of CEUS were measured with QLAB software.Results: the patients were divided into HCC and hemangioma groups according to pathologic findings. HCC group consist of 30 patients (21-83year;57.13土10.77 year)with 35 nodules in livers. Sizes of HCC nodules were 1.2-16.4cm,(4.78土2.88)cm in diameter. Hemangioma group consist of 27 patients(25-77year; 43.78土9.37 year) with 30 nodules in livers. Sizes of hemangiomas were 0.9-8.5cm,(4.1土2.46)cm in diameter. There was no significant difference in size of nodules(p>0.05)between two groups, but the ages of two groups were significant difference(p<0.05). In the 4 parameters of CEUS, there were significant difference in 3 parameters between hemangioma and HCC groups(P>0.05): A(2.83土1.12 vs14.84土7.5),а( 1.10土0.72 vs 0.17土0.06) , TP( 10.78土4.06 vs 7.46土5.27) .Conclusions: the characteristics of perfusion mode in nodules of liver can be reflected and the parameters can be got by CEUS, CEUS helps to identify the nodules in liver.
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