Gonadal Hormone Analysis In Patients With Pulmonary Artery Hypertension Secondary To Congenital Heart Disease

0bjective: To study the change of gonadal hormone in patients with pulmonary artery hypertension (PAH) secondary to congenital heart defects (CHD).Methods: A total of 144 patients with CHD including 36 patients with CHD and normal pulmonary arterial pressure were investigated. Their pulmonary artery pressure(PAP) was measured by right heart catheterization and the serum concentration of 17β-estradiol(E2),testosterone(TS), progesterone (PG),prolactin(PRL), follicle stimulating hormone (FSH)and luteinizing hormone ( LH ) were detected by chemiluminescence immunoassay.Results: The serum concentration of the E2, TS,PG,PRL and FSH in patients with PAH was significantly higher than that the patients with normal PAP(P<0.05).Multiple regression analysis showed that the concentration of gonadal hormones were not correlated with the site of shunt but physiologic factor including sex, age and menstrual cycle, and the level of mean pulmonary arterial pressure(mPAH). The multiple correlation coefficient of mPAP to PRL,E2 and PG was 0.518,0.607 and 0.531(P<0.05). The concentration of FSH was positively correlated with the prolactin and 17β-estradiol with a correlation coefficient of 0.917(P<0.05)and 0.759(P<0.05).Conclusions: The correlation between the concentration of gonadal hormones and the level of PAP suggests that gonadal hormones plays an important role in modification of the PAP in patients with PAH.