Investigation Of The Chronic Hepatitis B Patients With Hepatic Steatosis Of The Relevant Factors

Objective: To investigate the relevant factors of the chronic hepatitis B (CHB)patients with hepatic steatosis, as well as the relativity of hepatic steatosis and liver cell damage in CHB. Methods: Among 254 cases of patients, the liver biopsy by the merger of CHB patients with hepatic steatosis in 93 cases (A group), CHB unincorporated hepatic steatosis in patients with 87 cases (B group), and without hepatitis B virus (HBV) infection in non-alcoholic fatty liver disease (NAFLD) in patients with 74 cases (C group). To make statistical analysis for A, B, C three target groups of clinical data including gender, age, serological or virological target and target assessment of histology. Results: 1, the body mass index (BMI), fasting plasma glucose (FPG), total cholesterol (TCHO), triglycerides (TG) of A group were all higher than those of B group, the difference has statistical significance (P <0.05);however, the age, gender, hepatitis B virus deoxyribonucleic acid (HBV-DNA) of A, B two groups of patients were no significant difference (P>0.05). 2, the grades of liver inflammation activity for A, B groups of patients (G), fibrosis staging (S) were no significant difference (P>0.05); A ,B group of patients with intrahepatic hepatitis B virus surface antigen (HBsAg) and hepatitis B virus core antigen (HBcAg) expression were no significant difference (P>0.05). 3, A group of different degree of fatty degeneration of liver cells (F) of HBV-DNA level, hepatitis B virus e antigen (HBeAg) status, inflammatory activity grade (G), fibrosis staging (S), with intrahepatic expression of HBsAg and HBcAg were not significantly differences (P>0.05).4, The BMI, FPG, TCHO, TG of C group were higher than those of A group, and there is statistical significance (P<0.05); while for the age, gender in A,C groups, there was no significant difference (P>0.05). 5, alanine transferase,(ALT) in A, B, C three groups was no significant difference (P>0.05); Valley glutamyl transpeptidase (GGT) in A, B groups was no significant difference (P>0.05), but there was statistically significant differences (P<0.05) in A, C groups. Conclusion: The hepatic steatosis has something to do with the metabolic factors, including BMI, FPG, TCHO, TG, but no significant correlation to age, gender, and HBV. Hepatic steatosis has nothing to do with the liver inflammation activity and fibrosis degree, and the existence of hepatic steatosis doesn't influence HBV-DNA, HBeAg status and the expression of intrahepatic viral antigen. ALT increase level has no significance to distinguish the CHB patients'damage of liver cells virus inflammation and damage of liver cells fatty inflammation; GGT increase to some extent can point out the existence of NAFLD.