Clinicopathological Features And Endometrial Analysis Of Uterine Fibroids

Objective:The clinicopathologic characteristics and endometrial lesions in uterine leiomyoma were investigated.Methods:680 cases of uterine leiomyoma were performed by surgical treatment from January 2007 to January 2009 and their clinic characteristics, relevant factors with degeneration, postmenopausal clinicopathological characteristics and relationship with other estrogen-dependent gynecologic diseases were retrospective analysis. The endometrial lesions of 509 cases of uterine leiomyoma in the same period and relationship with patient`s age, irregular vaginal bleeding, postmenopausal bleeding, degeneration, numbers, clinical types, cellular myoma, other estrogen-dependent gynecologic diseases and other complications.Results: (1) The women between 31 and 50 is usually more likely to suffer from Uterine leiomyoma ,accounts for 79.41% of the total,Pelvic masses(45.88%) and uterine bleeding(33.68%) are the main clinical manifestations, the percentages are 45.88% and 33.68% respectively.14.12% of uterine leiomyoma degenerate, with Hyaline degeneration (of which) the most common, about 56.25%. the Uterine leiomyoma degeneration is related to age, the size of fibroid diameter and the pregnancy(P<0.05),And has nothing to do with the number of myoma growth(P>0.05). the person who are more than 50 and whose diameter myoma is above 9cm and who with pregnancy, has a significantly higher proportion of fibroid degeneration(P<0.05). Special type of uterine leiomyoma is 3.82%,in which cellular uterine leiomyoma is the most common, about 69.23%. the possibility for the people who has been in menopause and whose leiomyoma have been≥5cm to get cellular uterine leiomyoma were significantly higher than non-menopausal and myoma diameter<5cm (P<0.05),and has nothing to do with the number of fibroids(P>0.05). the percentage of Uterine fibroids in postmenopausal women is about 6.91%,among the Postmenopausal women with uterine fibroids ,10 cases of vaginal bleeding (21.28%),and three cases were in ombined gynecological malignancies group(30.00%). in which combined gynecological malignancies were three cases. The possibility of Uterine fibroids in postmenopausal vaginal bleeding who have a combined proportion of gynecological malignant tumors is significantly higher than those without uterine leiomyomas in postmenopausal vaginal bleeding (P<0.05). The possibility of Uterine fibroids in postmenopausal hypertension,diabetes and abnormal body mass index was significantly higher than the proportion of those who are not postmenopausal (P<0.05), but there is on obvious difference between the merger of the breast and thyroid disease (P>0.05). is not the proportion of post-menopausal compared with no significant difference .there are 80 cases of Merger Hysteromyoma adenomyosis (11.76%), 37 cases of endometriosis (5.4%) and 2 cases of endometrial cancer (0.29%).(2) The percentage of Hysteromyoma with endometrial lesions is about 21.61%,mainly distributed in the 41~55-year-old age group, accounting for 88.19% of the endometrial lesions ,≤40group and>55group years of age covers only 7.27% and 4.55% respectively,. the proportion of uterine fibroids with endometrial lesions in Age>45 group was significantly higher than age≤45 persons (P<0.05).there is no significant correlation between Uterine fibroids with endometrial lesions and whether the person is in menopause no (P>0.05).the percentage of Uterine leiomyoma with postmenopausal vaginal bleeding and non-menopausal with irregular vaginal bleeding,of which the proportion of endometrial lesions were significantly higher than in postmenopausal without vaginal bleeding and non-menopausal without vaginal bleeding(P<0.05).Cellular myoma combined the incidence of atypical hyperplasia was higher then non- cellular myoma.(P<0.05).Hysteromyoma with adenomyosis combined are the proportion of endometrial lesions was significantly higher than without the merger adenomyosis(P<0.05). Hysteromyoma endometrial lesions in patients has nothing to do with fibroid degeneration, Single or multiple, Clinical type(P>0.05),and has nothing to do with Whether or not the merger with hypertension, diabetes, abnormal body mass index, breast disease and unrelated thyroid disease(P>0.05).Conclusions:Postmenopausal uterine myoma and whose leiomyoma have been≥5cm diameter, the incidence of Cellular myoma has increased significantly. So is the incidence of Cellular myoma combined atypical hyperplasia the was significantly increased. the proportion of Uterine fibroids in postmenopausal vaginal bleeding who have a combined proportion of gynecological malignant tumors significantly increased.it is the same with the proportion of Age>45 years old, postmenopausal bleeding, no post-menopausal vaginal bleeding irregular and merging of adenomyosis (tumor) in patients with uterine myoma, the proportion of endometrial lesions were significantly increased. Hysteromyoma endometrial lesions in patients may have nothing to do with fibroid degeneration, Single or multiple, Clinical type,whether or not the merger with hypertension, diabetes, abnormal body mass index, breast disease and unrelated thyroid disease.