Treatment On NHL With Adoptive Immunotherapy: A Report Of One Case And Review

Objective:To evaluate the safety and therapeutic effect of adoptive immunotherapy for non-Hodgkin's lymphoma.Methods:A refractory and relapsed patient of non-Hodgkin's lymphoma diagnosed pathologically with bone marrow infiltration was collected.With the treatment of R-CHOP regimen combined with allogeneic CIK cells and autologous DC-CIK,we observed the therapeutic effect.Results:1.The patient's general condition improved significantly,living as a healthy people participating in work and daily life.2.Examination:After combined treatment,ultrasonography showed the tumor volume decreasing,although the lymph nodes grow up again during the maintenance therapy with AIT, the PET gave a negative result;Bone marrow biopsy indicated lymphoma cell disappeared;LDH and tumor-marker level was obviously lower than before;level descending;heteroploid cells disappeared;cytokine produced by Th1 cell increasing,ability of anti-cancer proving significance.3.Adverse effect:fever was the side effect during the therapy,other adverse effects were not observed.Conclusions:1.Adoptive immunotherapy has significant therapeutic effect to refractory and relapsed patients of NHL.2.Adoptive immunotherapy can improve the body's immune function and enhance the anti-cancer effect.3.Providing a potent immune therapeutic strategy for tumor patients.