A Preliminary Investigation Of Cognitive Dysfunction In Patient With Multiple Sclerosis

Objective:To investigate the characteristics of cognitive dysfunction in patients with multiple sclerosis(MS) and their relationships with magnetic resonance imaging(MRI) and neurological deficit.Methods:Totally 14 patients and 20 healthy controls were submitted to a wide neuropsychological battery,including Wechsler Intelligence Scale and Wisconsin Card Sorting Task et al,as to assess intelligences,executive function and other cognitive domains.All MS patients received brain MRI tests and expaned disability status Scale(EDSS) tests.Statistical analysis was performed by SPSS 13.0 softwares,P＜0.05 was considered statistically significant.Results:The scores of cognitive tests in MS group were significantly lower than those in control group.No significant correlations were found between cognitive dysfunction and lesions of brain on MRI and EDSS.Conclusion:Cognitive impairment is a common occurrence in MS.No significant correlations are found between cognitive dysfunction and lesions of brain on MRI.