The Value Of Application In Grading Of Cerebral Glioma With 3.0T~1 H-MRS

Objective: To approach the clinical application value of corr-quantitative analysis with 3.0T magnetic resonance spectroscopy (~1H-MRS) in grading of cerebral glioma before operation.Methods: 32 patients with cerebral glioma confirmed by pathological results were performed with ~1H-MRS scanner , GE 3.0T magnetic resonance system were usd.The spectral line in the solid area of tumour,hydroncus area of ambi-tumour and normal-area of opposite side were observed with ~1H-MRS.The quantitative ratio change of various kinds metabolism(Cho/ NAA,Cho/Cr,Lac or Lip/Cr,NAA/Cr,Cho/nCho)were analyzed. The results of ~1H-MRS were compared with the results of patholoy.Another 11 examples were normal control.Results: There were significant difference in Cho/ NAA,Cho/Cr,NAA/Cr between solid area of glioma with normal-area of opposite side(2.05±0.70,2.10±1.04,0.84±0.44;0.61±0.10,0.87±0.13,1.43±0.14)and Cho/NAA,Cho/Cr,NAA/Cr,Cho/nCr,Lac(Lip)/Cr between solid area in the low grade glioma group with that in the high grade glioma group (1.74±0.61,1.58±0.63,0.96±0.57,1.04±0.81, 1.58±0.10;3.35±0.89,2.62±1.45,0.78±0. 31,2.14±1.77, 2.61±2.75) (P<0.05). There were significant difference in Cho/NAA,Cho/Cr,Cho/nCho(2.21±0.49,1.12±0.23,2.09±0.82,1.47±1.13;1.43±0.32,0.82±0.45,1.22±0.19,1.23±0.36) between hydroncus area of low grade glioma group with high grade glioma group(P<0.05).Cho/NAA,Cho/Cr,Cho/nCho,Lac (Lip)/Cr(r =0.42,0.62,0.41,0.26)of solid area of tumor was positive correlation with grade of tumor,and NAA/C(rr =- 0.35)was negative correction.The correlation coefficient of Cho/ NAA(r =0.62)was the maximum and had max dependability with grade of tumor.Conclusion: ~1H-MRS had very significance clinical application value in provideing diagnosis support for grading of cerebral glioma before operation.