Endothelin, Endothelin Receptor Antagonists And Diabetic Nephropathy Pathogenesis

Diabetic nephropathy is the most common diabetic microvascular complication. The current study found that many more and more endothelin happened in its course of development has played a key role. It can be caused by renal hemodynamic changes, you can make tubulointerstitial injury, the accumulation of extracellular matrix, glomerular basement membrane thickening, mesangial proliferation, and promote inflammation, cell damage caused by foot and so on. And endothelin receptor antagonists can reduce proteinuria and improve renal blood flow, inhibit inflammation, reduce the extracellular matrix, inhibition of oxidative stress and reduce basement membrane thickening and reduce podocyte injury to improve renal function and prevent renal further deterioration.