Preparation Of Anti-tumor Activity Heteropolyvanadate Sustained-Release Polymer Microspheres

Chitosan and poly vinyl alcohol (PVA) had been widely used in Sustained-Release system, targeting drug delivery system and intelligent drug delivery system for their biocompatible, nontoxicity and biodegradable characteristics. In order to improve the efficiency of treatment and reduce the side effects of a kind of potential antitumor agent-polyoxometalate, two different polymer microspheres were made respectively using chitosan and PVA as materials while K7 [MnV13O38] ?18H2O were used as a model drug. The factors affecting the drug loading and incorporation efficiency in the preparation of microspheres were many, such as concentration of materials, cross-linking time, pH were evaluated and arranged in orthogonal experimental table to optimize the appropriate condition of the microspheres. The physicochemical properties of microspheres were investigated through FT-IR, UV-Vis spectra , TEM , SEM. The results showed that the microspheres had good morphology and narrow size distribution. And heteropolyvanadates were successfully embedded in these microspheres. In vitro release studies showed that the microspheres were useful as a potential delivery system for polyoxometalates due to their obvious sustained release characteristics.