| Objective Current investigations support the notion that postresuscitation myocardial dysfunction is one of the main causes which lead to deaths after initially successful cardiopulmonary resuscitation(CPR).As the preferred vasopressor agent,adrenaline has been confirmed to improve coronary and cerebral perfusion and enhance the restoration of spontaneous circulation(ROSC) during CPR widely in many clinical settings.However,some evidences showed that adrenaline increased the seveyity of postresuscitation myocardial dysfunction in consequence of itsβandα1-adrenergic actions during CPR.The present study is to observe the effects ofβ-andα1-adrenergic blocker on the changes of hemodynamic values and concentration of BNP after rabbits' cardiopulmonary resuscitation.Methods fourty-five rabbits were randomly allocated to one of 3 groups:sham control groug,adrenaline treatment group,metoprolol+urapidil pretreatment group(n=15,per group).Hemodynamic values and concentration of BNP were measured at different points of before ventricular tachycardia(VF) and 30,60,120,180minutes after CPR.Results The left cardiac function was significantly reduced in all rabbits.Heart rate(HR) was significantly higher after CPR in B group than in A and C group (P＜0.05).In B and C group,peak first derivative of left ventricular pressure(peak dp/dt) and left ventricle end diastolic pressure(LVEDP) were reduced compared with A group(P＜0.01).The BNP of B and C groups was conspicuous higher compared A group,and the increases could be observed at each postresuscitation time intervals (P＜0.01).The BNP of C group was lower than B group conspicuously(P＜0.01).Conclusions During cardiopulmonary resuscitationβ-andal-adrenergic blocker can reduce the concentration of BNP and improve postresuscitation myocardial dysfunction. |
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