The Study Of The Retinal Nerve Fiber Layer And The Neurosensory Retina In Macula Measurement Using Optical Coherence Tomography In High Myopia

Objective: (1) To measure the retinal nerve fiber layer (RNFL) thickness and the neurosensory retinal thickness and volume in macular using optical coherence tomography (OCT) in the high myopia patients, and to find the characters of them. (2) To analyze the changes of the retinal nerve fiber layer and the neurosensory retina in macular in myopia and glaucoma, and supply the parameters of OCT for early diagnosis of complicated glaucoma in myopia.Methods: Collected 60 subjects (60 eyes) of high myopia eyes and 50 subjects (50 eyes) of normal eyes, divided them into high myopia group and normal control group. (1) Thickness of the RNFL around the disc was determined with 3.4mm diameter circle OCT scan, and it was measured and analyzed using the Stratus-OCT. (2) The thickness and volume of the neurosensory retinal on OCT macular map was calculated automatically using Stratus-OCT. All examinations and measurements were done by the same examiner in the same condition.Results: (1) In the high myopia group, the average RNFL thickness of superior and inferior quadrants were thicker than that of the temporal quadrant, and the average RNFL thickness of the nasal quadrant was the thinnest one. The RNFL thickness of 7 : 00 and 11 : 00 positions were thicker than that of other point positions in the high myopia group, and that of 3: 00 position was the thinnest one. (2) The total, superior, inferior and nasal quadrants average RNFL thickness in the high myopia group became thinner than those in the normal control group (p﹤0.0001), especially the nasal quadrant. There was no statistically significant change in the temporal quadrant except who had diopter greater than -9.00D.(3) The degree of change in 7 : 00 and 11 : 00 positions was less than that in other positions in the same quadrant in the high myopia group. (4) In the high myopia group, the changes of the neurosensory retinal thickness and volume in the macula were similar. Superior and inferior quadrants were thicker than the temporal quadrant, and the nasal quadrant was the thinnest one. The inner ring was thicker than the outer ring in the same quadrant. (5) There were statistically significant changes for the macular neurosensory retinal thickness and volume in all regions in the high myopia group except B1. (6) In the high myopia group, there were no statistically significant differences in the degree of change of the macular neurosensory retinal thickness and volume between the outer rings in the superior and inferior quadrants (p﹥0 .05). (7) In the high myopia group, there weres no statistically significant differences in the macular neurosensory retinal thickness and volume between patients with -6.00～-9.00D and those with -9.25～-12.00D (p﹥0.05).Conclusion: (1) The total , superior, inferior and nasal quadrants average RNFL thickness in the high myopia group became thinner than those in the normal control group, especially the nasal quadrant, and the RNFL thickness became thinner significantly in all quadrants when diopter greater than -9.00D. (2) The macular neurosensory retinal thickness and volume in the high myopia group were less than those in the normal control group, and there was no significant correlation between the further change of neurosensory retinal thickness and volume and the diopter in patients with -6.00～-12.00D. (3) There were significant differences between the the parameters of OCT of myopia and glaucoma, and OCT could be used for early diagnosis of complicated glaucoma in myopia.